OSBPL9

OSBPL9
Identifiers
Aliases	OSBPL9, ORP-9, ORP9, oxysterol binding protein like 9
External IDs	OMIM: 606737; MGI: 1923784; GeneCards: OSBPL9
Gene location (Human)
Chr.	Chromosome 1 (human)
End	51,798,427 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	109,202,272 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; right lung; ; popliteal artery; ; tibial arteries; ; sural nerve; ; Epithelium of choroid plexus; ; renal medulla; ; retinal pigment epithelium; ; right coronary artery; ; gastric mucosa;
	Top expressed in
	stroma of bone marrow; ; right kidney; ; granulocyte; ; proximal tubule; ; carotid body; ; iris; ; ankle; ; conjunctival fornix; ; vestibular membrane of cochlear duct; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipid binding; sterol transporter activity; sterol binding;
Cellular component	endosome; Golgi apparatus; membrane; late endosome membrane; cytosol; intracellular membrane-bounded organelle;
Biological process	lipid transport; bile acid biosynthetic process; sterol transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	114883
	100273
	ENSG00000117859
	ENSMUSG00000028559
	Q96SU4
	A2A8Z1
NM_024586; NM_148904; NM_148905; NM_148906; NM_148907;
	NM_148908; NM_148909; NM_001330580; NM_001350208; NM_001350209; NM_001350210
NM_001134791; NM_133885; NM_173350; NM_001346502; NM_001355190;
	NM_001355191; NM_001368727
NP_001317509; NP_078862; NP_683702; NP_683703; NP_683704;
	NP_683705; NP_683706; NP_683707; NP_001337137; NP_001337138; NP_001337139
NP_001128263; NP_001333431; NP_598646; NP_775485; NP_001342119;
	NP_001342120; NP_001355656
	Wikidata
View/Edit Human	View/Edit Mouse

Oxysterol binding protein-like 9 is a protein that in humans is encoded by the OSBPL9 gene.

This gene encodes the ORP9 protein, a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid transfer proteins. ORP9 contains an N-terminal pleckstrin homology domain, a FFAT (two phenylalanines in an acidic tract) motif, and a highly conserved C-terminal OSBP-related domain (ORD). ORP9 functions as a phosphatidylserine transfer protein that regulates Golgi lipid levels, structure and function. ORP9 forms homo-dimers with by ORP10 or ORP11, products of OSBPL10 and OSBPL11 genes.

Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117859 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028559 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: oxysterol binding protein-like 9". Retrieved 2011-08-30.
↑ Wong LH, Gatta AT, Levine TP (February 2019). "Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes". Nature Reviews. Molecular Cell Biology. 20 (2): 85–101. doi:10.1038/s41580-018-0071-5. PMID 30337668.
1 2 Cabukusta B, Borst Pauwels S, Akkermans JJ, Blomberg N, Mulder AA, Koning RI, et al. (August 2024). "The ORP9-ORP11 dimer promotes sphingomyelin synthesis". eLife. 12 RP91345. doi:10.7554/eLife.91345. PMC 11302984. PMID 39106189.

Ngo M, Ridgway ND (March 2009). "Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function". Molecular Biology of the Cell. 20 (5): 1388–1399. doi:10.1091/mbc.E08-09-0905. PMC 2649274. PMID 19129476.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S (June 2009). "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach". Analytical Chemistry. 81 (11): 4493–4501. doi:10.1021/ac9004309. PMID 19413330.
Perttilä J, Merikanto K, Naukkarinen J, Surakka I, Martin NW, Tanhuanpää K, et al. (August 2009). "OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism". Journal of Molecular Medicine. 87 (8). Berlin, Germany: 825–835. doi:10.1007/s00109-009-0490-z. PMC 2707950. PMID 19554302.
Chen T, Huang Z, Wang L, Wang Y, Wu F, Meng S, et al. (July 2009). "MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages". Cardiovascular Research. 83 (1): 131–139. doi:10.1093/cvr/cvp121. PMID 19377067.
Wyles JP, Ridgway ND (July 2004). "VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein-9 between the endoplasmic reticulum and Golgi apparatus". Experimental Cell Research. 297 (2): 533–547. doi:10.1016/j.yexcr.2004.03.052. PMID 15212954.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Sowa ME, Bennett EJ, Gygi SP, Harper JW (July 2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, et al. (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". American Journal of Human Genetics. 85 (5): 628–642. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
Lessmann E, Ngo M, Leitges M, Minguet S, Ridgway ND, Huber M (February 2007). "Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation". Cellular Signalling. 19 (2): 384–392. doi:10.1016/j.cellsig.2006.07.009. PMID 16962287.
Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (December 2001). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–196. doi:10.1006/geno.2001.6663. PMID 11735225.
Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, et al. (August 2001). "The OSBP-related protein family in humans". Journal of Lipid Research. 42 (8): 1203–1213. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
Zhou Y, Li S, Mäyränpää MI, Zhong W, Bäck N, Yan D, et al. (November 2010). "OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface". Experimental Cell Research. 316 (19): 3304–3316. doi:10.1016/j.yexcr.2010.06.008. PMID 20599956.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, et al. (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–2253. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117859 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028559 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: oxysterol binding protein-like 9". Retrieved 2011-08-30.

[6] Wong LH, Gatta AT, Levine TP (February 2019). "Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes". Nature Reviews. Molecular Cell Biology. 20 (2): 85–101. doi:10.1038/s41580-018-0071-5. PMID 30337668.

[:1-7] 1 2 Cabukusta B, Borst Pauwels S, Akkermans JJ, Blomberg N, Mulder AA, Koning RI, et al. (August 2024). "The ORP9-ORP11 dimer promotes sphingomyelin synthesis". eLife. 12 RP91345. doi:10.7554/eLife.91345. PMC 11302984. PMID 39106189.

OSBPL9

References

Further reading