OST4

Available protein structures:
PDB	IPR018943 PF10215 (ECOD; PDBsum)
AlphaFold	IPR018943; PF10215;

Oligosaccaryltransferase
Oligosaccaryltransferase
	nmr structure of yeast oligosaccharyltransferase subunit ost4p
Identifiers
Symbol	Ost4
Pfam	PF10215
InterPro	IPR018943
OPM superfamily	242
OPM protein	2lat
Membranome	465
PDB
Available protein structures:
PDB	IPR018943 PF10215 (ECOD; PDBsum)
AlphaFold	IPR018943; PF10215;

OST4
Identifiers
Aliases	OST4, oligosaccharyltransferase complex subunit 4, non-catalytic
External IDs	GeneCards: OST4
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2LAT
Gene location (Human)
Chr.	Chromosome 2 (human)
End	27,071,654 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; skin of arm; ; left coronary artery; ; right coronary artery; ; right adrenal gland; ; right adrenal cortex; ; cardiac muscle tissue of right atrium; ; smooth muscle tissue; ; left adrenal gland;
	n/a
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	100128731
	n/a
	ENSG00000228474
	n/a
	P0C6T2
	n/a
	NM_001134693
	n/a
	NP_001128165
	n/a
	Wikidata
View/Edit Human

Oligosaccharyltransferase complex subunit 4, non-catalytic, also called Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 4, is a protein that in humans is encoded by the OST4 gene. This protein is a subunit of the oligosaccharyltransferase complex.

OST4 is a very short, approximately 30 amino acids, protein found from fungi to vertebrates. It appears to be an integral membrane protein that mediates the en bloc transfer of a pre-assembled high-mannose oligosaccharide onto asparagine residues of nascent polypeptides as they enter the lumen of the rough endoplasmic reticulum.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000228474 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kelleher DJ, Gilmore R (2006). "An evolving view of the eukaryotic oligosaccharyltransferase". Glycobiology. 16 (4): 47R–62R. doi:10.1093/glycob/cwj066. PMID 16317064.
↑ Gayen S, Kang C (2011). "Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex". Biochemical and Biophysical Research Communications. 409 (3): 572–576. doi:10.1016/j.bbrc.2011.05.050. PMID 21609714.
↑ Spirig U, Bodmer D, Wacker M, Burda P, Aebi M (2005). "The 3.4-kDa Ost4 protein is required for the assembly of two distinct oligosaccharyltransferase complexes in yeast". Glycobiology. 15 (12): 1396–1406. doi:10.1093/glycob/cwj025. hdl:20.500.11850/30954. PMID 16096346.

OST4

See also

References

Further reading