PARG

PARG
Identifiers
Aliases	PARG, PARG99, poly(ADP-ribose) glycohydrolase
External IDs	OMIM: 603501; MGI: 1347094; GeneCards: PARG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4B1J, 5A7R, 4A0D, 4B1I, 4B1H, 4B1G
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	49,970,203 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	32,019,507 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; germinal epithelium; ; testicle; ; kidney tubule; ; ventricular zone; ; epithelium of nasopharynx; ; ganglionic eminence; ; corpus callosum; ; gingival epithelium; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	Gonadal ridge; ; primitive streak; ; stria vascularis; ; pineal gland; ; epiblast; ; ureter; ; morula; ; tail of embryo; ; morula; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; poly(ADP-ribose) glycohydrolase activity; protein binding;
Cellular component	mitochondrial matrix; intracellular membrane-bounded organelle; mitochondrion; nucleus; nucleoplasm; cytoplasm; cytosol;
Biological process	ATP generation from poly-ADP-D-ribose; carbohydrate metabolic process; regulation of DNA repair; nucleotide-sugar metabolic process; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8505
	26430
	ENSG00000227345
	ENSMUSG00000021911
	Q86W56
	O88622
	NM_001303486; NM_001303487; NM_001303489; NM_003631; NM_001324381
	NM_011960; NM_001359915; NM_001374221
	NP_001290415; NP_001290416; NP_001290418; NP_001311310; NP_003622
	NP_036090; NP_001346844; NP_001361150
	Wikidata
View/Edit Human	View/Edit Mouse

Poly (ADP-ribose) glycohydrolase is an enzyme that in humans is encoded by the PARG gene.

Poly (ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly (ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000227345 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021911 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Poly (ADP-ribose) glycohydrolase". Retrieved 2011-11-08.
↑ Lin W, Amé JC, Aboul-Ela N, Jacobson EL, Jacobson MK (May 1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". The Journal of Biological Chemistry. 272 (18): 11895–11901. doi:10.1074/jbc.272.18.11895. PMID 9115250.
↑ Amé JC, Apiou F, Jacobson EL, Jacobson MK (1999). "Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization". Cytogenetics and Cell Genetics. 85 (3–4): 269–270. doi:10.1159/000015310. PMID 10449915. S2CID 42156664.

Affar EB, Germain M, Winstall E, Vodenicharov M, Shah RG, Salvesen GS, et al. (January 2001). "Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis". The Journal of Biological Chemistry. 276 (4): 2935–2942. doi:10.1074/jbc.M007269200. PMID 11053413.
Ohashi S, Kanai M, Hanai S, Uchiumi F, Maruta H, Tanuma S, et al. (August 2003). "Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells". Biochemical and Biophysical Research Communications. 307 (4): 915–921. Bibcode:2003BBRC..307..915O. doi:10.1016/S0006-291X(03)01272-5. PMID 12878198.
Meyer RG, Meyer-Ficca ML, Jacobson EL, Jacobson MK (September 2003). "Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23)". Gene. 314: 181–190. doi:10.1016/S0378-1119(03)00738-8. PMID 14527731.
Golovanov AP, Barillà D, Golovanova M, Hayes F, Lian LY (November 2003). "ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure". Molecular Microbiology. 50 (4): 1141–1153. doi:10.1046/j.1365-2958.2003.03750.x. PMID 14622405. S2CID 45704180.
Keil C, Petermann E, Oei SL (May 2004). "Tannins elevate the level of poly(ADP-ribose) in HeLa cell extracts". Archives of Biochemistry and Biophysics. 425 (1): 115–121. doi:10.1016/j.abb.2004.02.024. PMID 15081900.
Meyer-Ficca ML, Meyer RG, Coyle DL, Jacobson EL, Jacobson MK (July 2004). "Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments". Experimental Cell Research. 297 (2): 521–532. doi:10.1016/j.yexcr.2004.03.050. PMID 15212953.
Putt KS, Hergenrother PJ (October 2004). "A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation". Analytical Biochemistry. 333 (2): 256–264. doi:10.1016/j.ab.2004.04.032. PMID 15450800.
Bonicalzi ME, Haince JF, Droit A, Poirier GG (2005). "Poly-ADP-ribosylation in health and disease". Cellular and Molecular Life Sciences. 62 (7–8): 739–750. doi:10.1007/s00018-004-4505-1. PMC 11924541. PMID 15868399.
Gagné JP, Bonicalzi ME, Gagné P, Ouellet ME, Hendzel MJ, Poirier GG (December 2005). "Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles". The Biochemical Journal. 392 (Pt 3): 499–509. doi:10.1042/BJ20050792. PMC 1316289. PMID 16117724.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000227345 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021911 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: Poly (ADP-ribose) glycohydrolase". Retrieved 2011-11-08.

[Lin_1997-6] Lin W, Amé JC, Aboul-Ela N, Jacobson EL, Jacobson MK (May 1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". The Journal of Biological Chemistry. 272 (18): 11895–11901. doi:10.1074/jbc.272.18.11895. PMID 9115250.

[Amé_1999-7] Amé JC, Apiou F, Jacobson EL, Jacobson MK (1999). "Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization". Cytogenetics and Cell Genetics. 85 (3–4): 269–270. doi:10.1159/000015310. PMID 10449915. S2CID 42156664.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PARG

References

Further reading