PECR

PECR
Identifiers
Aliases	PECR, DCRRP, HPDHASE, HSA250303, PVIARL, SDR29C1, TERP, peroxisomal trans-2-enoyl-CoA reductase
External IDs	OMIM: 605843; MGI: 2148199; GeneCards: PECR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YXM
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	216,082,955 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	72,323,473 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; buccal mucosa cell; ; nipple; ; ventral tegmental area; ; synovial joint; ; cardia; ; trigeminal ganglion; ; subthalamic nucleus; ; external globus pallidus; ; spinal ganglia;
	Top expressed in
	right kidney; ; human kidney; ; left lobe of liver; ; zygote; ; primary oocyte; ; proximal tubule; ; secondary oocyte; ; lacrimal gland; ; parotid gland; ; epithelium of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; signaling receptor binding; 2,4-dienoyl-CoA reductase (NADPH) activity; trans-2-enoyl-CoA reductase (NADPH) activity;
Cellular component	peroxisome; mitochondrion; peroxisomal membrane; cytosol;
Biological process	phytol metabolic process; fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolism; fatty acid alpha-oxidation; protein targeting to peroxisome;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55825
	111175
	ENSG00000115425
	ENSMUSG00000026189
	Q9BY49
	Q99MZ7
	NM_018441
	NM_023523; NM_001356516
	NP_060911
	NP_076012; NP_001343445
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisomal trans-2-enoyl-CoA reductase is an enzyme that in humans is encoded by the PECR gene. Research suggests that the (human) enzyme participates in the conversion of phytol to phytanic acid in the peroxisomes, which is part of the process of breaking down phytol. In particular, it catalyzes reactions of the form:

a (2E)-enoyl-CoA + NADPH + H⁺

⇌

a 2,3-saturated acyl-CoA + NADP⁺

With affinity for trans-2-enoyl-CoAs of lengths between 4:1 and 16:1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115425 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026189 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Das AK, Uhler MD, Hajra AK (Sep 2000). "Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs". J Biol Chem. 275 (32): 24333–40. doi:10.1074/jbc.M001168200. PMID 10811639.
↑ Amery L, Mannaerts GP, Subramani S, et al. (Oct 2001). "Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology". Comb Chem High Throughput Screen. 4 (7): 545–52. doi:10.2174/1386207013330832. PMID 11669066.
↑ Persson B, Kallberg Y, Bray JE, et al. (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
↑ "Entrez Gene: PECR peroxisomal trans-2-enoyl-CoA reductase".
1 2 Gloerich J, Ruiter JP, van den Brink DM, et al. (2006-04-03). "Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation". FEBS Lett. 580 (8): 2092-6. doi:10.1016/j.febslet.2006.03.011. PMID 16546181.

Gay F, Anglade I, Gong Z, et al. (2001). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions". Mol. Endocrinol. 14 (10): 1627–48. doi:10.1210/mend.14.10.0538. PMID 11043578.
Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.
Braastad CD, Leguia M, Hendrickson EA (2002). "Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element". Nucleic Acids Res. 30 (8): 1713–24. doi:10.1093/nar/30.8.1713. PMC 113227. PMID 11937624.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115425 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026189 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10811639-5] Das AK, Uhler MD, Hajra AK (Sep 2000). "Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs". J Biol Chem. 275 (32): 24333–40. doi:10.1074/jbc.M001168200. PMID 10811639.

[pmid11669066-6] Amery L, Mannaerts GP, Subramani S, et al. (Oct 2001). "Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology". Comb Chem High Throughput Screen. 4 (7): 545–52. doi:10.2174/1386207013330832. PMID 11669066.

[pmid19027726-7] Persson B, Kallberg Y, Bray JE, et al. (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-8] "Entrez Gene: PECR peroxisomal trans-2-enoyl-CoA reductase".

[gloerich2006-9] 1 2 Gloerich J, Ruiter JP, van den Brink DM, et al. (2006-04-03). "Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation". FEBS Lett. 580 (8): 2092-6. doi:10.1016/j.febslet.2006.03.011. PMID 16546181.

PECR

See Also

References

Further reading