Phosphoglycerate mutase 1

PGAM1
Identifiers
Aliases	PGAM1, HEL-S-35, PGAM-B, PGAMA, phosphoglycerate mutase 1
External IDs	OMIM: 172250; MGI: 97552; GeneCards: PGAM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YFK, 1YJX, 4GPI, 4GPZ
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,433,444 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,907,099 bp
RNA expression pattern
	Top expressed in
	superior frontal gyrus; ; dorsolateral prefrontal cortex; ; right frontal lobe; ; mucosa of esophagus; ; right adrenal gland; ; Brodmann area 9; ; anterior cingulate cortex; ; right adrenal cortex; ; left adrenal gland; ; hypothalamus;
	Top expressed in
	tail of embryo; ; neural layer of retina; ; epiblast; ; embryo; ; cerebellar cortex; ; hippocampus proper; ; primary visual cortex; ; olfactory bulb; ; superior frontal gyrus; ; hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	intramolecular transferase activity, phosphotransferases; isomerase activity; bisphosphoglycerate mutase activity; protein binding; catalytic activity; hydrolase activity; protein kinase binding; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; phosphoglycerate mutase activity;
Cellular component	cytoplasm; cytosol; membrane; myelin sheath; extracellular exosome; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen; nucleus;
Biological process	gluconeogenesis; glycolytic process; canonical glycolysis; regulation of glycolytic process; respiratory burst; regulation of pentose-phosphate shunt; metabolism; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5223
	18648
	ENSG00000171314
	ENSMUSG00000011752
	P18669
	Q9DBJ1
	NM_002629; NM_001317079
	NM_023418
	NP_001304008; NP_002620
	NP_075907
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoglycerate mutase 1 is an enzyme that in humans is encoded by the PGAM1 gene. This enzyme functions as a phosphoglycerate mutase, and catalyzes a step of glycolysis (breaking down of glucose). This protein is notably expressed in the liver and brain, compared to phosphoglycerate mutase 2 which is mainly expressed in the muscles and heart.

Function

As a phosphoglycerate mutase (5.4.2.11), this enzyme is able to catalyze the following reaction (in both directions):

(2R)-2-phosphoglycerate

\rightleftharpoons

(2R)-3-phosphoglycerate

Despite its name, it is also able to function as a Bisphosphoglycerate mutase (EC 5.4.2.4) like its paralog BPGM:

(2R)-3-phospho-glyceroyl phosphate

\rightleftharpoons

(2R)-2,3-bisphosphoglycerate + H⁺

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171314 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000011752 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "PGAM1 phosphoglycerate mutase 1". Entrez Gene. NCBI. Retrieved 2026-09-20.
1 2 Li N, Liu X (2020-02-27). "Phosphoglycerate mutase 1: its glycolytic and non-glycolytic roles in tumor malignant behaviors and potential therapeutic significance". OncoTargets and therapy: 1787–95. doi:10.2147/OTT.S238920. PMC 7051807.
1 2 3 4 "Phosphoglycerate mutase 1". uniprot.org. UniProt consortium. Retrieved 2026-09-20.
↑ "Phosphoglycerate mutase 2". uniprot.org. UniProt consortium. Retrieved 2026-09-20.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171314 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000011752 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "PGAM1 phosphoglycerate mutase 1". Entrez Gene. NCBI. Retrieved 2026-09-20.

[LiLiu2020-6] 1 2 Li N, Liu X (2020-02-27). "Phosphoglycerate mutase 1: its glycolytic and non-glycolytic roles in tumor malignant behaviors and potential therapeutic significance". OncoTargets and therapy: 1787–95. doi:10.2147/OTT.S238920. PMC 7051807.

[uniprot-7] 1 2 3 4 "Phosphoglycerate mutase 1". uniprot.org. UniProt consortium. Retrieved 2026-09-20.

[8] "Phosphoglycerate mutase 2". uniprot.org. UniProt consortium. Retrieved 2026-09-20.

v t e Isomerase: mutases (EC 5.4)
5.4.1 Acyl Groups	Lysolecithin acylmutase Precorrin-8X methylmutase
5.4.2 Phosphomutases	Phosphoglycerate mutase Bisphosphoglycerate mutase Phosphoglucomutase Phosphomannomutase PMM1 PMM2 Phosphoenolpyruvate mutase
5.4.99 Other groups	Cycloartenol synthase Lanosterol synthase Lupeol synthase Methylmalonyl-CoA mutase