PIGV

PIGV

Identifiers

PIGV, GPI-MT-II, HPMRS1, PIG-V, phosphatidylinositol glycan anchor biosynthesis class V

External IDs

OMIM: 610274; MGI: 2442480; GeneCards: PIGV

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1p36.11	Start	26,787,472 bp
Band	1p36.11	End	26,798,398 bp

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)

Band	4\|4 D2.3	Start	133,387,698 bp
Band	4\|4 D2.3	End	133,399,958 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

sperm

oocyte

right testis

left testis

germinal epithelium

bronchial epithelial cell

secondary oocyte

gonad

parotid gland

kidney tubule

Top expressed in

otic vesicle

granulocyte

interventricular septum

ascending aorta

aortic valve

spermatocyte

yolk sac

right kidney

muscle of thigh

hand

More reference expression data


More reference expression data

Gene ontology
Molecular function	mannosyltransferase activity glycosyltransferase activity transferase activity glycolipid mannosyltransferase activity
Cellular component	membrane mannosyltransferase complex endoplasmic reticulum integral component of membrane endoplasmic reticulum membrane
Biological process	GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane mannosylation
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


55650


230801


ENSG00000060642


ENSMUSG00000043257


Q9NUD9


Q7TPN3

RefSeq (mRNA)


NM_017837 NM_001202554


NM_001145955 NM_001145956 NM_178698 NM_001356466

RefSeq (protein)

NP_001189483 NP_060307 NP_001361407 NP_001361409 NP_001361410
NP_001361411 NP_001361412 NP_001361413 NP_001361414 NP_001361415


NP_001139427 NP_001139428 NP_848813 NP_001343395

Location (UCSC)

Chr 1: 26.79 – 26.8 Mb

Chr 4: 133.39 – 133.4 Mb

PubMed search

View/Edit Human

View/Edit Mouse

GPI mannosyltransferase 2 is an enzyme that in humans is encoded by the PIGV gene.

See also

Hyperphosphatasia with mental retardation syndrome (HPMRS)

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000060642 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043257 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kang JY, Hong Y, Ashida H, Shishioh N, Murakami Y, Morita YS, Maeda Y, Kinoshita T (Mar 2005). "PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol". J Biol Chem. 280 (10): 9489–97. doi:10.1074/jbc.M413867200. PMID 15623507.
↑ "Entrez Gene: PIGV phosphatidylinositol glycan anchor biosynthesis, class V".

Further reading

Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Fabre AL, Orlean P, Taron CH (2005). "Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly". FEBS J. 272 (5): 1160–8. doi:10.1111/j.1742-4658.2005.04551.x. PMID 15720390. S2CID 25106178.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Metabolism: lipid metabolism / fatty acid metabolism, triglyceride and fatty acid enzymes

Synthesis

Malonyl-CoA synthesis	ATP citrate synthase Acetyl-CoA carboxylase
Fatty acid synthesis/ Fatty acid synthase	Beta-ketoacyl-ACP synthase Beta-Ketoacyl ACP reductase 3-Hydroxyacyl ACP dehydrase Enoyl ACP reductase
Fatty acid desaturases	Stearoyl-CoA 9-desaturase
Triacyl glycerol	Glycerol-3-phosphate dehydrogenase Thiokinase

General	Acyl-CoA dehydrogenase ACADL ACADM ACADS ACADVL ACADSB Enoyl-CoA hydratase MTP: HADH HADHA HADHB Acetyl-CoA C-acyltransferase
Unsaturated	Enoyl-CoA isomerase 2,4 Dienoyl-CoA reductase
Odd chain	Propionyl-CoA carboxylase
Other	Hydroxyacyl-Coenzyme A dehydrogenase

Malonyl-CoA decarboxylase

Long-chain-aldehyde dehydrogenase

Anabolism

to diacylglycerol: Acyltransferase Phosphatidate phosphatase 2C
Choline kinase CHKA CHKB Choline-phosphate cytidylyltransferase
phosphatidylinositol glycan anchor biosynthesis: PIGA PIGB PIGC PIGF PIGG PIGH PIGK PIGL PIGM PIGN PIGO PIGP PIGQ PIGS PIGT PIGU PIGV PIGW PIGX PIGY PIGZ
cardiolipin: Tafazzin

Catabolism

Phospholipase C
Diacylglycerol kinase DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ
Phosphoric monoester hydrolases Inositol-phosphate phosphatase

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