PNLIPRP2

PNLIPRP2
Identifiers
Aliases	PNLIPRP2, PLRP2, pancreatic lipase related protein 2 (gene/pseudogene)
External IDs	OMIM: 604423; MGI: 1336202; GeneCards: PNLIPRP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OXE, 2PVS
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	116,645,143 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	58,765,966 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; jejunal mucosa; ; duodenum; ; islet of Langerhans; ; rectum; ; mucosa of ileum; ; mucosa of sigmoid colon; ; pancreatic epithelial cell; ; mucosa of transverse colon; ; testicle;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; pyloric antrum; ; Paneth cell; ; epithelium of stomach; ; mucous cell of stomach; ; islet of Langerhans; ; jejunum; ; duodenum; ; ileum; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; phospholipase activity; carboxylic ester hydrolase activity; hydrolase activity; metal ion binding; triglyceride lipase activity; acylglycerol lipase activity; galactolipase activity; 1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity; lipase activity;
Cellular component	extracellular region; extracellular space;
Biological process	lipid catabolic process; galactolipid catabolic process; lipid digestion; triglyceride metabolic process; lipid metabolism; phospholipid catabolic process; cellular defense response; intestinal lipid catabolic process; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5408
	18947
	ENSG00000266200
	ENSMUSG00000025091
	P54317
	P17892
	NM_005396
	NM_011128
	NP_005387
	NP_035258
	Wikidata
View/Edit Human	View/Edit Mouse

Pancreatic lipase related protein 2 (or PLRP2) is an enzyme that in humans is encoded by the PNLIPRP2 gene. PLRP2 is a digestive enzyme and lipase that is found in pancreatic juice. Nonsense mutations in PNLIPRP2 (eg: W358X) are very common in certain ethnic groups, with allele frequencies as high as 30-50%, and notably the allele in the reference genome is a non-coding allele. PLRP2 is part of the pancreatic lipase family.

Function

Like many lipases, one of PLRP2's main functions is to break down triglycerides. However, it is distinct from other lipases found in humans by being able to act on galactosylglycerides, making it a galactolipase. Since the primary digestive lipase, pancreatic lipase, is not expressed in newborn human babies, it is thought that PLRP2 may play a role in their digestion of lipids.

Like pancreatic lipase, PLRP2 is secreted by pancreatic acinar cells into an enzyme-rich fluid called pancreatic juice. This fluid is released into the first part of the small intestines (the duodenum) in response to eating, which triggers nerve signaling and the release of hormones like cholecystokinin.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000266200 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025091 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "P54317 · LIPR2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-10.
1 2 3 4 Lim SY, Steiner JM, Cridge H (2022-08-01). "Lipases: it's not just pancreatic lipase!". American journal of veterinary research. 83 (8). doi:10.2460/ajvr.22.03.0048.
1 2 Zhu G, Fang Q, Zhu F, Huang D, Yang C (2021-07-05). "Structure and function of pancreatic lipase-related protein 2 and its relationship with pathological states". Frontiers in Genetics. 12. doi:10.3389/fgene.2021.693538. PMC 8287333.
↑ "PNLIPRP2 - pancreatic lipase related protein 2 (gene/pseudogene)".
↑ "ENZYME entry: EC 3.1.1.26". enzyme.expasy.org. SIB Swiss Institute of Bioinformatics. Retrieved 2026-09-10.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000266200 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025091 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] 1 2 3 "P54317 · LIPR2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-10.

[Lim2022-6] 1 2 3 4 Lim SY, Steiner JM, Cridge H (2022-08-01). "Lipases: it's not just pancreatic lipase!". American journal of veterinary research. 83 (8). doi:10.2460/ajvr.22.03.0048.

[Zhu2021-7] 1 2 Zhu G, Fang Q, Zhu F, Huang D, Yang C (2021-07-05). "Structure and function of pancreatic lipase-related protein 2 and its relationship with pathological states". Frontiers in Genetics. 12. doi:10.3389/fgene.2021.693538. PMC 8287333.

[entrez-8] "PNLIPRP2 - pancreatic lipase related protein 2 (gene/pseudogene)".

[9] "ENZYME entry: EC 3.1.1.26". enzyme.expasy.org. SIB Swiss Institute of Bioinformatics. Retrieved 2026-09-10.