Paramethasone acetate

Paramethasone acetate
Clinical data
Other namesMonocortin
Drug classCorticosteroid; Glucocorticoid
Identifiers
  • 2-[(1S,2R,8S,10S,11S,13R,14R,15S,17S)-8-Fluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-14-yl]-2-oxoethyl acetate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.014.989 Edit this at Wikidata
Chemical and physical data
FormulaC24H31FO6
Molar mass434.504 g·mol−1
3D model (JSmol)
  • [H][C@@]1(C)C[C@@]2([H])[C@]3([H])C[C@]([H])(F)C4=CC(=O)C=C[C@]4(C)[C@@]3([H])[C@@]([H])(O)C[C@]2(C)[C@@]1(O)C(=O)COC(C)=O
  • InChI=1S/C24H31FO6/c1-12-7-16-15-9-18(25)17-8-14(27)5-6-22(17,3)21(15)19(28)10-23(16,4)24(12,30)20(29)11-31-13(2)26/h5-6,8,12,15-16,18-19,21,28,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19+,21-,22+,23+,24+/m1/s1
  • Key:HYRKAAMZBDSJFJ-LFDBJOOHSA-N

Paramethasone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is the acetate ester of paramethasone.

Chemistry

Paramethasone acetate is the acetate ester derivative of paramethasone, a fluorinated glucocorticoid corticosteroid. It has the molecular formula C24H31FO6 and a molecular weight of 434.5 g/mol.

Pharmacology

Paramethasone acetate is a synthetic glucocorticoid corticosteroid and the acetate ester of paramethasone. Like other glucocorticoids, it exerts anti-inflammatory and immunosuppressive effects by binding to glucocorticoid receptors and regulating the expression of genes involved in inflammatory and immune responses.

Names and identifiers

Paramethasone acetate has been marketed under the trade name Monocortin. The compound has the CAS Registry Number 1597-82-6 and is listed in several chemical and pharmaceutical databases, including PubChem, DrugBank, ChEBI, and KEGG.

History

Paramethasone acetate was developed as a synthetic glucocorticoid corticosteroid during the expansion of corticosteroid drug research in the mid-twentieth century. The drug was marketed under trade names including Monocortin and Haldrone and was in clinical use by the early 1970s, when studies evaluating injectable formulations were published.

According to pharmaceutical reference databases, paramethasone acetate was originally developed by Eli Lilly and received approval in the United States in 1961.

References

  1. 1 2 3 4 PubChem. "Paramethasone Acetate". pubchem.ncbi.nlm.nih.gov. Retrieved 2026-06-04.
  2. ↑ PubChem. "Paramethasone acetate (JAN/USAN)". pubchem.ncbi.nlm.nih.gov. Retrieved 2026-06-04.
  3. 1 2 "Compound: PARAMETHASONE ACETATE (CHEMBL1200342)". www.ebi.ac.uk. Retrieved 2026-06-04.
  4. ↑ "KEGG DRUG: Paramethasone acetate". www.kegg.jp. Retrieved 2026-06-04.
  5. ↑ "Delving into the Latest Updates on Paramethasone Acetate with Synapse". synapse.patsnap.com. Retrieved 2026-06-04.