Picoplatin

Picoplatin
Names
IUPAC name
azane; 2-methylpyridine; platinum(2+); dichloride
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.205.233 Edit this at Wikidata
UNII
  • InChI=1S/C6H7N.2ClH.H3N.Pt/c1-6-4-2-3-5-7-6;;;;/h2-5H,1H3;2*1H;1H3;/q;;;;+2/p-2 X markN
    Key: IIMIOEBMYPRQGU-UHFFFAOYSA-L X markN
  • InChI=1/C6H7N.2ClH.H3N.Pt/c1-6-4-2-3-5-7-6;;;;/h2-5H,1H3;2*1H;1H3;/q;;;;+2/p-2
    Key: IIMIOEBMYPRQGU-NUQVWONBAG
  • ionic form: Cc1ccccn1.N.[Cl-].[Cl-].[Pt+2]
  • coordination form: Cl[Pt-2](Cl)([NH3+])[n+]1ccccc1C
Properties
C6H10Cl2N2Pt
Molar mass 376.14 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Picoplatin is a platinum-based antineoplastic agent in clinical development by Poniard Pharmaceuticals (previously NeoRx) for the treatment of patients with solid tumors.

In Phase I and Phase II clinical trials, picoplatin demonstrated activity in a variety of solid tumors, including lung, ovarian, colorectal and hormone-refractory prostate cancer. However, in Phase III trials, picoplatin failed to hit its primary endpoint for advanced small cell lung cancer. Hopes are now pinned on its use for metastatic colorectal cancer.

References

  1. ↑ Wheate, Nial J. (2010). "The status of platinum anticancer drugs in the clinic and in clinical trials" (PDF). Dalton Transactions. 39 (35): 8113–8127. doi:10.1039/C0DT00292E. hdl:2123/14271. PMID 20593091.
  2. ↑ Picoplatin Clinical Results, Poniard Pharmaceuticals
  3. ↑ Poniard shares crash on Phase III picoplatin failure, fiercebiotech.com, November 16, 2009
  4. ↑ http://www.genengnews.com/specialreports/sritem.aspx?oid=69418732 Nov 2009