RTF1

RTF1
Identifiers
Aliases	RTF1, GTL7, KIAA0252, RTF1 homolog, Paf1/RNA polymerase II complex component
External IDs	OMIM: 611633; MGI: 1309480; GeneCards: RTF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BZE, 2DB9, 3U1U, 4L1P, 4L1U
Gene location (Human)
Chr.	Chromosome 15 (human)
End	41,483,563 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	119,735,407 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Skeletal muscle tissue of rectus abdominis; ; palpebral conjunctiva; ; epithelium of colon; ; ventricular zone; ; bone marrow cell; ; cerebellar hemisphere; ; Skeletal muscle tissue of biceps brachii; ; body of tongue; ; monocyte;
	Top expressed in
	tail of embryo; ; zygote; ; genital tubercle; ; hand; ; yolk sac; ; superior cervical ganglion; ; foot; ; interventricular septum; ; primitive streak; ; fossa;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; single-stranded DNA binding; DNA binding; RNA polymerase II C-terminal domain phosphoserine binding; RNA binding;
Cellular component	nucleolus; nucleus; Cdc73/Paf1 complex; nucleoplasm;
Biological process	blastocyst growth; histone modification; regulation of transcription, DNA-templated; positive regulation of transcription elongation from RNA polymerase II promoter; histone H3-K4 trimethylation; positive regulation of histone H3-K4 methylation; transcription, DNA-templated; Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; stem cell population maintenance; endodermal cell fate commitment; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23168
	76246
	ENSG00000137815
	ENSMUSG00000027304
	Q92541
	A2AQ19
	NM_015138
	NM_030112
	NP_055953
	NP_084388
	Wikidata
View/Edit Human	View/Edit Mouse

Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) is a protein that in humans is encoded by the RTF1 gene. As its name suggests, this protein is part of the Paf1/RNA polymerase II complex, a multi-subunit complex involved in regulating DNA to RNA transcription by RNA polymerase II.

This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137815 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027304 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)". Retrieved 2011-09-20.
↑ "RNA polymerase-associated protein RTF1 homolog". uniprot.org. UniProt consortium. Retrieved 2026-09-15.

Rozenblatt-Rosen O, Hughes CM, Nannepaga SJ, Shanmugam KS, Copeland TD, Guszczynski T, et al. (January 2005). "The parafibromin tumor suppressor protein is part of a human Paf1 complex". Molecular and Cellular Biology. 25 (2): 612–620. doi:10.1128/MCB.25.2.612-620.2005. PMC 543415. PMID 15632063.
Warner MH, Roinick KL, Arndt KM (September 2007). "Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification". Molecular and Cellular Biology. 27 (17): 6103–6115. doi:10.1128/MCB.00772-07. PMC 1952162. PMID 17576814.
de Jong RN, Truffault V, Diercks T, Ab E, Daniels MA, Kaptein R, et al. (January 2008). "Structure and DNA binding of the human Rtf1 Plus3 domain". Structure. 16 (1): 149–159. doi:10.1016/j.str.2007.10.018. hdl:1874/33204. PMID 18184592. S2CID 38494347.
Nordick K, Hoffman MG, Betz JL, Jaehning JA (July 2008). "Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II". Eukaryotic Cell. 7 (7): 1158–1167. doi:10.1128/EC.00434-07. PMC 2446681. PMID 18469135.
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, et al. (October 2010). "Hundreds of variants clustered in genomic loci and biological pathways affect human height". Nature. 467 (7317): 832–838. Bibcode:2010Natur.467..832L. doi:10.1038/nature09410. PMC 2955183. PMID 20881960.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, et al. (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–329, 341–329. doi:10.1093/dnares/3.5.321. PMID 9039502.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000137815 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027304 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)". Retrieved 2011-09-20.

[uniprot-6] "RNA polymerase-associated protein RTF1 homolog". uniprot.org. UniProt consortium. Retrieved 2026-09-15.

RTF1

See also

References

Further reading