Replication termination factor 2

RTF2
Identifiers
Aliases	RTF2, C20orf43, CDAO5, HSPC164, SHUJUN-3, replication termination factor 2 domain containing 1, replication termination factor 2, RTFDC1
External IDs	MGI: 1913654; GeneCards: RTF2
Gene location (Human)
Chr.	Chromosome 20 (human)
End	56,519,449 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	172,311,828 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; monocyte; ; popliteal artery; ; gastrocnemius muscle; ; ganglionic eminence; ; prefrontal cortex; ; caudate nucleus; ; ascending aorta; ; left coronary artery; ; right coronary artery;
	Top expressed in
	spermatid; ; granulocyte; ; lip; ; spermatocyte; ; dentate gyrus of hippocampal formation granule cell; ; left lobe of liver; ; neural tube; ; thymus; ; lumbar spinal ganglion; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	molecular function; DNA binding; protein binding;
Cellular component	nucleus; cellular component; replication fork; chromosome;
Biological process	mitotic DNA replication termination; site-specific DNA replication termination at RTS1 barrier; biological process; cellular response to hydroxyurea; regulation of DNA stability;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51507
	66404
	ENSG00000022277
	ENSMUSG00000027502
	Q9BY42
	Q99K95
	NM_001283035; NM_001283036; NM_001283037; NM_016407
	NM_025542; NM_175297
	NP_001269964; NP_001269965; NP_001269966; NP_057491
	NP_079818
	Wikidata
View/Edit Human	View/Edit Mouse

Replication termination factor 2 is a protein that in humans is encoded by the RTF2 gene. The RTF2 protein is a DNA binding protein that research suggests plays a role in DNA damage response and repair, but its precise functions remains uncertain.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000022277 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027502 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "RTF2 replication termination factor 2 [ Homo sapiens (human) ]".
↑ "Q9BY42 · RTF2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-03.

External links

Human RTFDC1 genome location and RTFDC1 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000022277 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027502 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "RTF2 replication termination factor 2 [ Homo sapiens (human) ]".

[6] "Q9BY42 · RTF2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-03.

Replication termination factor 2

See also

References

External links

Further reading