SH3PXD2A

SH3PXD2A

Identifiers

SH3PXD2A, FISH, SH3MD1, TKS5, SH3 and PX domains 2A

External IDs

MGI: 1298393; GeneCards: SH3PXD2A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DNU, 2EGA, 2EGC, 2EKH

Gene location (Human)

Chr.	Chromosome 10 (human)

Band	10q24.33	Start	103,594,027 bp
Band	10q24.33	End	103,855,543 bp

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)

Band	19\|19 C3	Start	47,248,613 bp
Band	19\|19 C3	End	47,452,840 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

cervix

sural nerve

trigeminal ganglion

tibia

inferior ganglion of vagus nerve

myometrium

vagina

cecum

tendon

Top expressed in

molar

gastrula

ascending aorta

sciatic nerve

aortic valve

body of femur

umbilical cord

calvaria

skin of abdomen

utricle

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding superoxide-generating NADPH oxidase activator activity phosphatidylinositol binding protease binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-5-phosphate binding phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,4-bisphosphate binding phosphatidylinositol-4-phosphate binding
Cellular component	cytoplasm podosome cell junction cell projection cytosol
Biological process	osteoclast fusion superoxide metabolic process reactive oxygen species metabolic process positive regulation of catalytic activity podosome assembly extracellular matrix organization
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9644


14218


ENSG00000107957


ENSMUSG00000053617


Q5TCZ1


O89032

RefSeq (mRNA)


NM_014631 NM_001365079


NM_001164717 NM_008018 NM_177833

RefSeq (protein)


NP_055446 NP_001352008


NP_001158189 NP_032044

Location (UCSC)

Chr 10: 103.59 – 103.86 Mb

Chr 19: 47.25 – 47.45 Mb

PubMed search

View/Edit Human

View/Edit Mouse

SH3 and PX domain-containing protein 2A is a protein that in humans is encoded by the SH3PXD2A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107957 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053617 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lock P, Abram CL, Gibson T, Courtneidge SA (Sep 1998). "A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate". EMBO J. 17 (15): 4346–57. doi:10.1093/emboj/17.15.4346. PMC 1170768. PMID 9687503.
↑ "Entrez Gene: SH3PXD2A SH3 and PX domains 2A".

Further reading

Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Abram CL, Seals DF, Pass I, et al. (2003). "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells". J. Biol. Chem. 278 (19): 16844–51. doi:10.1074/jbc.M300267200. PMID 12615925.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Seals DF, Azucena EF, Pass I, et al. (2005). "The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells". Cancer Cell. 7 (2): 155–65. doi:10.1016/j.ccr.2005.01.006. PMID 15710328.
Malinin NL, Wright S, Seubert P, et al. (2005). "Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 3058–63. Bibcode:2005PNAS..102.3058M. doi:10.1073/pnas.0408237102. PMC 549444. PMID 15710903.
Harold D, Jehu L, Turic D, et al. (2007). "Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (4): 448–52. doi:10.1002/ajmg.b.30456. PMID 17440933. S2CID 13922599.

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