SLC15A2

SLC15A2
Identifiers
Aliases	SLC15A2, PEPT2, solute carrier family 15 member 2
External IDs	OMIM: 602339; MGI: 1890457; GeneCards: SLC15A2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	121,944,188 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	36,605,324 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; bronchial epithelial cell; ; palpebral conjunctiva; ; corpus epididymis; ; mucosa of paranasal sinus; ; parotid gland; ; olfactory zone of nasal mucosa; ; seminal vesicula; ; trachea; ; epithelium of nasopharynx;
	Top expressed in
	epithelium of lens; ; conjunctival fornix; ; olfactory epithelium; ; right kidney; ; vestibular membrane of cochlear duct; ; human kidney; ; neural layer of retina; ; parotid gland; ; Epithelium of choroid plexus; ; seminal vesicula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptide:proton symporter activity; protein binding; symporter activity; transporter activity; transmembrane transporter activity; oligopeptide transmembrane transporter activity; dipeptide transmembrane transporter activity; peptide transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	protein transport; peptide transport; oligopeptide transport; ion transport; transmembrane transport; transport; dipeptide transmembrane transport; oligopeptide transmembrane transport; proton transmembrane transport; xenobiotic detoxification by transmembrane export across the plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6565
	57738
	ENSG00000163406
	ENSMUSG00000022899
	Q16348
	Q9ES07
	NM_001145998; NM_021082
	NM_001145899; NM_021301
	NP_001139470; NP_066568
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 15 (H+/peptide transporter), member 2, also known as SLC15A2, is a human gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163406 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022899 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SLC15A2 solute carrier family 15 (H+/peptide transporter), member 2".

Liu W, Liang R, Ramamoorthy S, et al. (1995). "Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney". Biochim. Biophys. Acta. 1235 (2): 461–6. doi:10.1016/0005-2736(95)80036-F. PMID 7756356.
Döring F, Martini C, Walter J, Daniel H (2002). "Importance of a small N-terminal region in mammalian peptide transporters for substrate affinity and function". J. Membr. Biol. 186 (2): 55–62. doi:10.1007/s00232-001-0135-9. PMID 11944083. S2CID 11211548.
Alcorn J, Lu X, Moscow JA, McNamara PJ (2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". J. Pharmacol. Exp. Ther. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627. S2CID 16195525.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Groneberg DA (2003). "[Expression, localization and functional aspects of the peptide transporter PEPT2 in the normal respiratory tract and in cystic fibrosis]". Pneumologie (Stuttgart, Germany). 57 (2): 104–5. doi:10.1055/s-2003-37158. PMID 12579467.
Terada T, Irie M, Okuda M, Inui K (2004). "Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function". Biochem. Biophys. Res. Commun. 316 (2): 416–20. doi:10.1016/j.bbrc.2004.02.063. PMID 15020234.
Pinsonneault J, Nielsen CU, Sadée W (2005). "Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions". J. Pharmacol. Exp. Ther. 311 (3): 1088–96. doi:10.1124/jpet.104.073098. PMID 15282265. S2CID 12947228.
Bahadduri PM, D'Souza VM, Pinsonneault JK, et al. (2005). "Functional characterization of the peptide transporter PEPT2 in primary cultures of human upper airway epithelium". Am. J. Respir. Cell Mol. Biol. 32 (4): 319–25. doi:10.1165/rcmb.2004-0322OC. PMID 15626774.
Zhang EY, Emerick RM, Pak YA, et al. (2005). "Comparison of human and monkey peptide transporters: PEPT1 and PEPT2". Mol. Pharm. 1 (3): 201–10. doi:10.1021/mp0499712. PMID 15981923.
Noshiro R, Anzai N, Sakata T, et al. (2006). "The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity". Kidney Int. 70 (2): 275–82. doi:10.1038/sj.ki.5001522. PMID 16738539.
Søndergaard H, Bravo S, Nielsen CU, et al. (2008). "Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1". Eur. J. Pharm. Sci. 33 (4): 332–42. doi:10.1016/j.ejps.2008.01.001. PMID 18295462.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163406 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022899 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SLC15A2 solute carrier family 15 (H+/peptide transporter), member 2".

SLC15A2

See also

References

Further reading