GLUT8

SLC2A8
Identifiers
Aliases	SLC2A8, GLUT8, GLUTX1, solute carrier family 2 member 8
External IDs	OMIM: 605245; MGI: 1860103; GeneCards: SLC2A8
Gene location (Human)
Chr.	Chromosome 9 (human)
End	127,408,424 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,872,095 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; right adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; muscle layer of sigmoid colon; ; right hemisphere of cerebellum; ; C1 segment; ; right lobe of liver; ; gastrocnemius muscle;
	Top expressed in
	spermatocyte; ; parotid gland; ; ankle; ; seminiferous tubule; ; spermatid; ; motor neuron; ; seminal vesicula; ; right kidney; ; muscle of thigh; ; stroma of bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane transporter activity; transporter activity; carbohydrate:proton symporter activity; glucose binding; glucose transmembrane transporter activity; D-glucose transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; synaptic vesicle; plasma membrane; integral component of plasma membrane; lysosomal membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle; clathrin-coated vesicle membrane;
Biological process	insulin receptor signaling pathway; response to hypoxia; glucose transmembrane transport; male meiosis I; glucose import; carbohydrate transport; transmembrane transport; membrane organization; hexose transmembrane transport; transport; carbohydrate metabolic process; proton transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	29988
	56017
	ENSG00000136856
	ENSMUSG00000026791
	Q9NY64
	Q9JIF3
	NM_001271711; NM_001271712; NM_014580
	NM_019488; NM_001356409
	NP_001258640; NP_001258641; NP_055395
	NP_062361; NP_001343338
	Wikidata
View/Edit Human	View/Edit Mouse

GLUT8 is a protein that in humans is encoded by the gene SLC2A8. It is the eighth member of glucose transporter superfamily.

It is characterized by the presence of two leucine residues in its N-terminal intracellular domain, which influences intracellular trafficking.

Discovery

GLUT8, originally named GLUTX1, was cloned almost simultaneously by two different groups.

Subcellular localization

Where in the cell GLUT8 is localized in not yet clear. Most GLUT8 is not present at the cell surface. Some co-localization with both the endoplasmic reticulum and late endosomes/lysosomes has been published.

Physiological role

GLUT8 function in vivo remains to be defined, despite suggestions that it may play a role in fertility, being expressed at high levels in testes and in the acrosomal part of spermatozoa. Furthermore, GLUT8 appears to play an important role in the energy metabolism of sperm cells.

GLUT8, when expressed in Xenopus oocytes, mediates glucose uptake with high affinity. Other hexoses are not good substrates of the transporter.

Mice devoid of both copies of the SLC2A8 gene are viable, fertile and do not show any obvious phenotype.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136856 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026791 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Uldry M, Thorens B (February 2004). "The SLC2 family of facilitated hexose and polyol transporters" (PDF). Pflügers Arch. 447 (5): 480–9. doi:10.1007/s00424-003-1085-0. PMID 12750891. S2CID 25539725.
1 2 Ibberson M, Uldry M, Thorens B (2000). "GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues". J. Biol. Chem. 275 (7): 4607–12. doi:10.1074/jbc.275.7.4607. PMID 10671487.
↑ Doege H, Schürmann A, Bahrenberg G, Brauers A, Joost HG (2000). "GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity". J. Biol. Chem. 275 (21): 16275–80. doi:10.1074/jbc.275.21.16275. PMID 10821868.
↑ Widmer M, Uldry M, Thorens B (2005). "GLUT8 subcellular localization and absence of translocation to the plasma membrane in PC12 cells and hippocampal neurons". Endocrinology. 146 (11): 4727–36. doi:10.1210/en.2005-0668. PMID 16109784.
↑ Schürmann A, Axer H, Scheepers A, Doege H, Joost HG (February 2002). "The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa". Cell Tissue Res. 307 (2): 237–42. doi:10.1007/s00441-001-0499-2. PMID 11845330. S2CID 20138373.
↑ Gawlik V, Schmidt S, Scheepers A, Wennemuth G, Augustin R, Aumüller G, Moser M, Al-Hasani H, Kluge R, Joost HG, Schürmann A (April 2008). "Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa". Mol. Membr. Biol. 25 (3): 224–35. doi:10.1080/09687680701855405. PMC 2557070. PMID 18428038.
↑ Membrez M, Hummler E, Beermann F, Haefliger JA, Savioz R, Pedrazzini T, Thorens B (2006). "GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function". Mol. Cell. Biol. 26 (11): 4268–76. doi:10.1128/MCB.00081-06. PMC 1489108. PMID 16705176.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136856 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026791 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12750891-5] Uldry M, Thorens B (February 2004). "The SLC2 family of facilitated hexose and polyol transporters" (PDF). Pflügers Arch. 447 (5): 480–9. doi:10.1007/s00424-003-1085-0. PMID 12750891. S2CID 25539725.

[pmid10671487-6] 1 2 Ibberson M, Uldry M, Thorens B (2000). "GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues". J. Biol. Chem. 275 (7): 4607–12. doi:10.1074/jbc.275.7.4607. PMID 10671487.

[pmid10821868-7] Doege H, Schürmann A, Bahrenberg G, Brauers A, Joost HG (2000). "GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity". J. Biol. Chem. 275 (21): 16275–80. doi:10.1074/jbc.275.21.16275. PMID 10821868.

[pmid16109784-8] Widmer M, Uldry M, Thorens B (2005). "GLUT8 subcellular localization and absence of translocation to the plasma membrane in PC12 cells and hippocampal neurons". Endocrinology. 146 (11): 4727–36. doi:10.1210/en.2005-0668. PMID 16109784.

[pmid11845330-9] Schürmann A, Axer H, Scheepers A, Doege H, Joost HG (February 2002). "The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa". Cell Tissue Res. 307 (2): 237–42. doi:10.1007/s00441-001-0499-2. PMID 11845330. S2CID 20138373.

[pmid18428038-10] Gawlik V, Schmidt S, Scheepers A, Wennemuth G, Augustin R, Aumüller G, Moser M, Al-Hasani H, Kluge R, Joost HG, Schürmann A (April 2008). "Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa". Mol. Membr. Biol. 25 (3): 224–35. doi:10.1080/09687680701855405. PMC 2557070. PMID 18428038.

[pmid16705176-11] Membrez M, Hummler E, Beermann F, Haefliger JA, Savioz R, Pedrazzini T, Thorens B (2006). "GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function". Mol. Cell. Biol. 26 (11): 4268–76. doi:10.1128/MCB.00081-06. PMC 1489108. PMID 16705176.