SOCS4

SOCS4
Identifiers
Aliases	SOCS4, SOCS7, suppressor of cytokine signaling 4
External IDs	OMIM: 616337; MGI: 1914546; GeneCards: SOCS4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IZV
Gene location (Human)
Chr.	Chromosome 14 (human)
End	55,049,489 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	47,533,559 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; tibia; ; visceral pleura; ; parietal pleura; ; tail of epididymis; ; germinal epithelium; ; mucosa of ileum; ; mucosa of paranasal sinus; ; cardiac muscle tissue of right atrium; ; tibialis anterior muscle;
	Top expressed in
	medial ganglionic eminence; ; conjunctival fornix; ; vestibular membrane of cochlear duct; ; epithelium of small intestine; ; carotid body; ; atrioventricular valve; ; lymph node; ; trigeminal ganglion; ; lumbar spinal ganglion; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase inhibitor activity; protein binding;
Cellular component	cytoplasm; intracellular anatomical structure;
Biological process	negative regulation of epidermal growth factor-activated receptor activity; regulation of growth; negative regulation of signal transduction; intracellular signal transduction; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; cytokine-mediated signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	122809
	67296
	ENSG00000180008
	ENSMUSG00000048379
	Q8WXH5
	Q91ZA6
	NM_080867; NM_199421
	NM_080843
	NP_543143; NP_955453
	NP_543119
	Wikidata
View/Edit Human	View/Edit Mouse

Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.

Function

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000180008 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048379 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Suppressor of cytokine signaling 4". Retrieved 2016-02-23.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Suppressor of cytokine signaling 4 (SOCS4)

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000180008 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048379 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Suppressor of cytokine signaling 4". Retrieved 2016-02-23.

SOCS4

Function

References

Further reading

External links