SRD5A3

SRD5A3
Identifiers
Aliases	SRD5A3, CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1, steroid 5 alpha-reductase 3
External IDs	OMIM: 611715; MGI: 1930252; GeneCards: SRD5A3
Enzyme activity
Gene location (Human)
Chr.	Chromosome 4 (human)
End	55,373,100 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	76,303,351 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; gallbladder; ; olfactory zone of nasal mucosa; ; mucosa of esophagus; ; body of pancreas; ; skin of thigh; ; gingival epithelium; ; gonad; ; C1 segment; ; epithelium of nasopharynx;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; secondary oocyte; ; zygote; ; primary oocyte; ; internal carotid artery; ; yolk sac; ; lip; ; external carotid artery; ; stroma of bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors; cholestenone 5-alpha-reductase activity; oxidoreductase activity; 3-oxo-5-alpha-steroid 4-dehydrogenase activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; polyprenol reductase activity;
Cellular component	cytoplasm; integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	lipid metabolism; polyprenol catabolic process; androgen biosynthetic process; protein glycosylation; dolichol metabolic process; dolichyl diphosphate biosynthetic process; dolichol-linked oligosaccharide biosynthetic process; dolichol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	79644
	57357
	ENSG00000128039
	ENSMUSG00000029233
	Q9H8P0
	Q9WUP4
	NM_024592
	NM_020611
	NP_078868
	NP_065636
	Wikidata
View/Edit Human	View/Edit Mouse

Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene. It is one of three forms of 5α-reductase. Unlike SRD5A1 and SRD5A2, SRD5A3 has no apparent form in androgen processing or signaling. Instead, SRD5A3 reduces polyprenol to dolichol, which is necessary for N-linked glycosylation of proteins and some lipids.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000128039 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029233 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: steroid 5 alpha-reductase 3".
↑ Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, et al. (January 2008). "Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer". Cancer Science. 99 (1): 81–86. doi:10.1111/j.1349-7006.2007.00656.x. PMC 11158902. PMID 17986282. S2CID 51733620.
↑ Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, et al. (July 2010). "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder". Cell. 142 (2): 203–217. doi:10.1016/j.cell.2010.06.001. PMC 2940322. PMID 20637498.

v t e Oxidoreductases: CH–CH oxidoreductases (EC 1.3)
1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase 7-Dehydrocholesterol reductase Biliverdin reductase 2,4 Dienoyl-CoA reductase Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase
1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase Coproporphyrinogen III oxidase Protoporphyrinogen oxidase Bilirubin oxidase Acyl-CoA oxidase Dihydrouracil oxidase Tetrahydroberberine oxidase Secologanin synthase Tryptophan alpha,beta-oxidase Pyrroloquinoline-quinone synthase L-galactonolactone oxidase
1.3.5: Quinone	Succinate dehydrogenase SDHA SDHB SDHC SDHD
1.3.99: Other acceptors	Fumarate reductase Butyryl-CoA dehydrogenase Acyl CoA dehydrogenase ACADSB ACADS 5α-reductase SRD5A1 SRD5A2 SRD5A3 Glutaryl-CoA dehydrogenase Isovaleryl coenzyme A dehydrogenase 3-oxo-5beta-steroid 4-dehydrogenase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

SRD5A3

See also

References

Further reading