Santa Cruz Xitla | |
|---|---|
Municipality and town | |
| Coordinates: 16°19′N 96°40′W / 16.317°N 96.667°W | |
| Country | |
| State | Oaxaca |
| Time zone | UTC-6 (Central Standard Time) |

Santa Cruz Xitla is a town and municipality in Oaxaca in south-western Mexico. The municipality covers an area of km2. It is part of the Miahuatlán District in the south of the Sierra Sur Region.
As of 2005, the municipality had a total population of 3,933.
Municipal president Pedro Modesto Santos died of COVID-19 in September 2020. He was the eighth municipal president in Oaxaca to die of the virus.