Speio and her other sisters appear to Thetis when she cries out in sympathy for the grief of Achilles at the slaying of his friend Patroclus.
In some accounts, Spio, together with her sisters Cymodoce, Nesaea and Thalia, was one of the nymphs in the train of Cyrene. Later on, these four together with their other sisters Thetis, Melite and Panopea, were able to help the hero Aeneas and his crew during a storm.
↑Virgil, Georgics 4.338 "But his mother heard the cry from her bower beneath the river's depths. About her the Nymphs were spinning fleeces of Miletus, dyed with rich glassy hue – Drymo and Xantho, Ligea and Phyllodoce, their shining tresses floating over snowy necks; Nesaea and Spio, Thalia and Cymodoce [four Nereids];"