Streptopain

Streptopain
Identifiers
EC no.3.4.22.10
CAS no.9025-51-8
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Streptopain, also known as streptococcal pyrogenic exotoxin B (SpeB) is a streptococcal cysteine protease. Other names include Streptococcus peptidase A, Streptococcus protease, and streptococcal cysteine proteinase. Streptopain catalyses the following chemical reaction

Preferential cleavage with hydrophobic residues at P2, P1 and P1'

It is isolated from the group A bacterium Streptococcus pyogenes and acts as a virulence factor.

See also

References

  1. ↑ Elliott SD, Liu TY (1970). "Streptococcal proteinase". Proteolytic Enzymes. Methods Enzymol. Vol. 19. pp. 252–261. doi:10.1016/0076-6879(70)19019-7. ISBN 978-0-12-181881-4.
  2. ↑ Liu TY, Elliott SD (1971). "Streptococcal proteinase". In Boyer, P.D. (ed.). The Enzymes (3rd ed.). New York: Academic Press. pp. 609–647.
  3. ↑ Tai JY, Kortt AA, Liu TY, Elliott SD (April 1976). "Primary structure of streptococcal proteinase. III. Isolation of cyanogen bromide peptides: complete covalent structure of the polypeptide chain". The Journal of Biological Chemistry. 251 (7): 1955–9. doi:10.1016/S0021-9258(17)33640-2. PMID 1270417.
  4. ↑ Lo SS, Fraser BA, Liu TY (September 1984). "The mixed disulfide in the zymogen of streptococcal proteinase. Characterization and implication for its biosynthesis". The Journal of Biological Chemistry. 259 (17): 11041–5. doi:10.1016/S0021-9258(18)90619-8. PMID 6381494.