TECTB

TECTB

Identifiers

TECTB, tectorin beta

External IDs

OMIM: 602653; MGI: 109574; GeneCards: TECTB

Gene location (Human)

Chr.	Chromosome 10 (human)

Band	10q25.2	Start	112,283,400 bp
Band	10q25.2	End	112,305,038 bp

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)

Band	19 D2\|19 51.13 cM	Start	55,169,165 bp
Band	19 D2\|19 51.13 cM	End	55,184,745 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

retinal pigment epithelium

liver

right lobe of liver

right lobe of thyroid gland

putamen

temporal lobe

mesencephalon

left lobe of thyroid gland

substantia nigra

ventricular zone

Top expressed in

vestibular sensory epithelium

organ of Corti

utricle

epithelium of macula of utricle of membranous labyrinth

embryo

cochlea

saccule

epithelium of macula of saccule of membranous labyrinth

vestibular membrane of cochlear duct

stria vascularis

More reference expression data

n/a

Gene ontology
Molecular function	extracellular matrix structural constituent
Cellular component	anchored component of membrane membrane extracellular region plasma membrane extracellular matrix
Biological process	C-terminal protein lipidation
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


6975


21684


ENSG00000119913


ENSMUSG00000024979


Q96PL2


O08524

RefSeq (mRNA)


NM_058222


NM_009348

RefSeq (protein)


NP_478129


NP_033374

Location (UCSC)

Chr 10: 112.28 – 112.31 Mb

Chr 19: 55.17 – 55.18 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Beta-tectorin is a protein that in humans is encoded by the TECTB gene.

Function

The genes for alpha-tectorin and beta-tectorin (this protein) encode the major noncollagenous proteins of the tectorial membrane of the cochlea.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119913 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024979 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: tectorin beta".

Further reading

Legan PK, Rau A, Keen JN, Richardson GP (1997). "The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system". J. Biol. Chem. 272 (13): 8791–801. doi:10.1074/jbc.272.13.8791. PMID 9079715.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Protein: scleroproteins

Extracellular
matrix

Fibril forming	type I COL1A1 COL1A2 type II (COL2A1) type III type V COL5A1 COL5A2 COL5A3 COL24A1 COL26A1
Other	FACIT: type IX COL9A1 COL9A2 COL9A3 type XII (COL12A1) COL14A1 COL16A1 COL19A1 COL20A1 COL21A1 COL22A1 basement membrane: type IV COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 multiplexin: COL15A1 type XVIII COL18A1 Endostatin transmembrane: COL13A1 COL17A1 COL23A1 COL25A1 other: type VI COL6A1 COL6A2 COL6A3 COL6A5 type VII (COL7A1) type VIII COL8A1 COL8A2 type X (COL10A1) type XI COL11A1 COL11A2 COL27A1 COL28A1
Enzymes	Prolyl hydroxylase/Lysyl hydroxylase Cartilage associated protein/Leprecan ADAMTS2 Procollagen peptidase Lysyl oxidase

alpha
- LAMA1
- LAMA2
- LAMA3
- LAMA4
- LAMA5
beta
- LAMB1
- LAMB2
- LAMB3
- LAMB4
gamma
- LAMC1
- LAMC2
- LAMC3

Other

Other

See also: diseases

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.