Tegileridine

Tegileridine

Clinical data
Trade names	艾苏特 (Aisute, AiSuTe)
Other names	AiSuTe; SHR-8554; SHR8554
Drug class	μ-Opioid receptor agonist; Opioid; Analgesic
Legal status
Legal status	Rx in China
Identifiers
IUPAC name (1S,4S)-4-Ethoxy-N-[2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethyl]-1,2,3,4-tetrahydronaphthalen-1-amine
CAS Number	2095345-66-5
PubChem CID	129049969
UNII	YFJS8L4TGU
Chemical and physical data
Formula	C28H38N2O2
Molar mass	434.624 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCO[C@H]1CC[C@@H](C2=CC=CC=C12)NCC[C@]3(CCOC4(C3)CCCC4)C5=CC=CC=N5
InChI InChI=1S/C28H38N2O2/c1-2-31-25-13-12-24(22-9-3-4-10-23(22)25)29-19-16-27(26-11-5-8-18-30-26)17-20-32-28(21-27)14-6-7-15-28/h3-5,8-11,18,24-25,29H,2,6-7,12-17,19-21H2,1H3/t24-,25-,27+/m0/s1 Key:YUMLNLMFBWBKSK-OHSXHVKISA-N

Tegileridine, sold under the brand name Aisute, is a drug which acts as a μ-opioid receptor agonist. It is closely related to compounds such as oliceridine, TRV734, and SHR9352, and shares a similar profile as a biased agonist selective for activation of the G protein signalling pathway over β-arrestin2 recruitment.

In January 2024, tegileridine was approved in China under the brand name Aisute for the treatment of moderate to severe pain after abdominal surgery.

See also

• μ-Opioid receptor § Biased agonists

References