Estradiol diundecylate/hydroxyprogesterone heptanoate/testosterone cyclohexylpropionate

EDU/OHPH/TCHP
Combination of
Estradiol diundecylateEstrogen
Hydroxyprogesterone heptanoateProgestogen
Testosterone cyclohexylpropionateAndrogen; Anabolic steroid
Clinical data
Trade namesTrioestrine Retard
Other namesEDU/OHPH/TCHP
Routes of
administration		Intramuscular injection

Estradiol diundecylate/hydroxyprogesterone heptanoate/testosterone cyclohexylpropionate (EDU/OHPH/TCHP), sold under the brand name Trioestrine Retard, is an injectable combination medication of estradiol diundecylate (EDU), an estrogen, hydroxyprogesterone heptanoate (OHPH), a progestogen, and testosterone cyclohexylpropionate (TCHP), an androgen/anabolic steroid. It contained 2.25 mg EDU, 100 mg OHPH, and 67.5 mg TCHP in oil solution, was provided as ampoules, and was administered by intramuscular injection. The medication was manufactured by Roussel and Théramex and was marketed by 1953. It is no longer available.

See also

References

  1. 1 2 Herschberg AD (October 1960). "[The menopause and the treatment of its disorders by a long-acting multihormone complex: trioestrine lente]". Gazette Médicale de France (in French). 67: 1987–1996. PMID 13713782.
  2. 1 2 Krówczyński L (1987). Extended Release Dosage Forms. CRC Press. p. 13. ISBN 978-0-8493-4307-0. Hydroxyprogesterone heptanoate + testosterone cyclohexylpropionate + oestradiol undecanoate. Trioestrine-RetardR (Theramex). Oily solution for injection.
  3. 1 2 Kleemann A, Engel J (2001). Pharmaceutical substances: syntheses, patents, applications. Thieme. p. 1998. ISBN 978-3-13-558404-1.
  4. ↑ Bordier, Philippe (1963). "Cure of fifteen osteoporosis cases by a delayed effect of hormonal association". Semaine des Hopitaux. 39 (2): 81–4. ISSN 0037-1777. The patients (females) received intramuscularly, every 10 days for 2-3 months, estradiol diundecyleate 2.25, testosterone cyclohexylpropionate 67.5, and hydroxyprogesterone heptylate 100 mg. ("trioestrine retard"). Their av. calcuria decreased 30.5% (0-69%) and asthenia, anorexia, and muscular activity improved.
  5. ↑ France (1964). Journal officiel de la République française. Spécialité dénommée Trioestrine retard Theramex, soluté injectable I. M. : [...] Composition : heptylate d'hydroxy-17 alpha-progestérone, 10 g; cyclohexyl propionate de testostérone, 10 g; di-undécylate d'œstradiol, 0,5 g; excipient Q. S. P. 100 ml (en boîtes de 2 ampoules de 1 ml).
  6. ↑ France (March 1953). Journal officiel de la République française. pp. 2564–.
  7. ↑ "Home". micromedexsolutions.com.
  8. ↑ "Trioestrine". Drugs.com.[permanent dead link]