Y-box-binding protein 2

YBX2
Identifiers
Aliases	YBX2, CONTRIN, CSDA3, DBPC, MSY2, Y-box binding protein 2
External IDs	OMIM: 611447; MGI: 1096372; GeneCards: YBX2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,294,639 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,941,605 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; mucosa of transverse colon; ; duodenum; ; gonad; ; medulla oblongata; ; testicle; ; rectum; ; skeletal muscle tissue; ; muscle of thigh;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; zygote; ; primary oocyte; ; secondary oocyte; ; muscle of thigh; ; neural layer of retina; ; interventricular septum; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; fibrillar center;
Biological process	regulation of transcription, DNA-templated; translational attenuation; transcription by RNA polymerase II; spermatogenesis; oocyte development; regulation of transcription by RNA polymerase II; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51087
	53422
	ENSG00000006047; ENSG00000288504
	ENSMUSG00000018554
	Q9Y2T7
	Q9Z2C8
	NM_015982
	NM_016875; NM_001347634
	NP_057066
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Y-box-binding protein 2 is a protein that in humans is encoded by the YBX2 gene. The YBX2 protein is a transcription factor that is expressed in sperm and egg cells which binds to both DNA (at promotors) and messenger RNA.

References

1 2 3 ENSG00000288504 GRCh38: Ensembl release 89: ENSG00000006047, ENSG00000288504 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018554 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tekur S, Pawlak A, Guellaen G, Hecht NB (Jul 1999). "Contrin, the human homologue of a germ-cell Y-box-binding protein: cloning, expression, and chromosomal localization". J Androl. 20 (1): 135–44. doi:10.1002/j.1939-4640.1999.tb02506.x. PMID 10100484.
↑ Gu W, Tekur S, Reinbold R, Eppig JJ, Choi YC, Zheng JZ, Murray MT, Hecht NB (Dec 1998). "Mammalian male and female germ cells express a germ cell-specific Y-Box protein, MSY2". Biol Reprod. 59 (5): 1266–74. doi:10.1095/biolreprod59.5.1266. PMID 9780336.
1 2 "Entrez Gene: YBX2 Y box binding protein 2".

Hammoud S, Emery BR, Dunn D, et al. (2009). "Sequence alterations in the YBX2 gene are associated with male factor infertility". Fertil. Steril. 91 (4): 1090–5. doi:10.1016/j.fertnstert.2008.01.009. PMID 18339382.
Yoshida T, Izumi H, Uchiumi T, et al. (2006). "Expression and cellular localization of dbpC/Contrin in germ cell tumor cell lines". Biochim. Biophys. Acta. 1759 (1–2): 80–8. doi:10.1016/j.bbaexp.2006.02.005. PMID 16624424.
Kohno Y, Matsuki Y, Tanimoto A, et al. (2006). "Expression of Y-box-binding protein dbpC/contrin, a potentially new cancer/testis antigen". Br. J. Cancer. 94 (5): 710–6. doi:10.1038/sj.bjc.6602987. PMC 2361212. PMID 16479255.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000288504 GRCh38: Ensembl release 89: ENSG00000006047, ENSG00000288504 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018554 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10100484-5] Tekur S, Pawlak A, Guellaen G, Hecht NB (Jul 1999). "Contrin, the human homologue of a germ-cell Y-box-binding protein: cloning, expression, and chromosomal localization". J Androl. 20 (1): 135–44. doi:10.1002/j.1939-4640.1999.tb02506.x. PMID 10100484.

[pmid9780336-6] Gu W, Tekur S, Reinbold R, Eppig JJ, Choi YC, Zheng JZ, Murray MT, Hecht NB (Dec 1998). "Mammalian male and female germ cells express a germ cell-specific Y-Box protein, MSY2". Biol Reprod. 59 (5): 1266–74. doi:10.1095/biolreprod59.5.1266. PMID 9780336.

[entrez-7] 1 2 "Entrez Gene: YBX2 Y box binding protein 2".

Y-box-binding protein 2

See also

References

Further reading