After moving back to Korea, Yu worked at Korea Research Institute of Bioscience and Biotechnology until 2000. After that, she has been working at Korea Institute of Science and Technology, holding a position of a principle research scientist. Much of Yu's work has focused on unlocking the structure and folding of the proteinalpha-1 antitrypsin, which is a serpin protein. Yu and her research team have worked to discover what amino acids can suppress certain types of mutations, such as the tsf mutation which is a protein folding error. She has also patented the alpha-1 antitrypsin mutein with a disulfide bond and the method for preparing it along with her research group.
Yu served as the Director of the Functional Proteomics Center, a part of the 21st Century Frontier R&D Program, at the Korea Institute of Science and Technology from July 2002 to July 2010. In 2010, she was appointed to a new post in the South Korean government: senior officer for national future. Her responsibilities included overseeing government communications regarding science and technology and to help promote low-carbon and green technologies. She also served as the president of the Korean Biophysical Society from 2009 to 2010, and the president of the Korea Genome Organization in 2010.
↑김창엽 [Gim Chang-yeop] (9 July 1998). "파워우먼: 생명공학연구소 유명희 박사"[Power woman: Dr. Yu Myeong-Hee, Research Institute of Biology and Biotechnology]. JoongAng Ilbo. Retrieved 3 November 2015.
↑Lee, Kye-Woo (2006). Advancement of Women in Science and Technology: A Case Study of Korea. Seoul, South Korea: Ewha Womans University Press. p.196. ISBN978-8973007035.
↑Mitraki, Anna; Fane, Ben; Haase-Pettingell, Cameron; King, Jonathan (1991). "Mutations Affecting Protein Folding and Misfolding In Vivo". In Kelly, Jeffrey W.; Baldwin, Thomas O. (eds.). Applications of Enzyme Biotechnology – Springer. Springer Science + Business Media. p.134. doi:10.1007/978-1-4757-9235-5. ISBN978-1-4757-9235-5. S2CID12057122.
↑Yu, Myeong-Hee; Lee, Kee Nyung; Kim, Jeongho (1 May 1995). "The Z type variation of human α1-antitrypsin causes a protein folding defect". Nature Structural & Molecular Biology. 2 (5): 363–367. doi:10.1038/nsb0595-363. PMID7664092. S2CID39389671.
↑Kim, Hye-Jung; Kang, Hyun Ju; Lee, Hanna; Lee, Seung-Taek; Yu, Myeong-Hee; Kim, Hoguen; Lee, Cheolju (6 March 2009). "Identification of S100A8 and S100A9 as Serological Markers for Colorectal Cancer". Journal of Proteome Research. 8 (3): 1368–1379. doi:10.1021/pr8007573. ISSN1535-3893. PMID19186948.