ZNF598

ZNF598
Identifiers
Aliases	ZNF598, zinc finger protein 598, HEL2, zinc finger protein 598, E3 ubiquitin ligase
External IDs	OMIM: 617508; MGI: 2670965; GeneCards: ZNF598
Enzyme activity
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,009,821 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,900,990 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; body of pancreas; ; skin of abdomen; ; sural nerve; ; minor salivary glands; ; granulocyte; ; anterior pituitary; ; right hemisphere of cerebellum; ; right lobe of liver; ; mucosa of transverse colon;
	Top expressed in
	gallbladder; ; superior surface of tongue; ; lactiferous gland; ; zygote; ; crypt of lieberkuhn of small intestine; ; Ileal epithelium; ; choroid plexus of fourth ventricle; ; secondary oocyte; ; primary oocyte; ; lip;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	90850
	213753
	ENSG00000167962
	ENSMUSG00000041130
	Q86UK7
	Q80YR4
	NM_178167; NM_001405664; NM_001405665
	NM_183149; NM_001348231
	NP_835461
	NP_898972; NP_001335160
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 598 (ZNF598) is a protein that in humans is encoded by the ZNF598 gene.

Function

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. ZNF598 and its yeast homologue Hel2 are ubiquitin ligases that ubiquitinate the 40S ribosomal subunit during ribosome-associated protein quality control.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167962 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041130 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Zinc finger protein 598".
↑ Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, et al. (September 2012). "A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development". Molecular and Cellular Biology. 32 (17): 3585–3593. doi:10.1128/MCB.00455-12. PMC 3422012. PMID 22751931.
↑ Juszkiewicz S, Hegde RS (February 2017). "Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination". Molecular Cell. 65 (4): 743–750.e4. doi:10.1016/j.molcel.2016.11.039. PMC 5316413. PMID 28065601.
↑ Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ (February 2017). "ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation". Molecular Cell. 65 (4): 751–760.e4. doi:10.1016/j.molcel.2016.12.026. PMC 5321136. PMID 28132843.
↑ Sitron CS, Park JH, Brandman O (May 2017). "Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation". RNA. 23 (5). New York, N.Y.: 798–810. doi:10.1261/rna.060897.117. PMC 5393187. PMID 28223409.
↑ Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, et al. (July 2017). "Ubiquitination of stalled ribosome triggers ribosome-associated quality control". Nature Communications. 8 (1) 159. Bibcode:2017NatCo...8..159M. doi:10.1038/s41467-017-00188-1. PMC 5534433. PMID 28757607.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000167962 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041130 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zinc finger protein 598".

[6] Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, et al. (September 2012). "A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development". Molecular and Cellular Biology. 32 (17): 3585–3593. doi:10.1128/MCB.00455-12. PMC 3422012. PMID 22751931.

[Juszkiewicz_Hegde_2017_pp._743–750.e4-7] Juszkiewicz S, Hegde RS (February 2017). "Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination". Molecular Cell. 65 (4): 743–750.e4. doi:10.1016/j.molcel.2016.11.039. PMC 5316413. PMID 28065601.

[Sundaramoorthy_Leonard_Mak_Liao_2017_pp._751–760.e4-8] Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ (February 2017). "ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation". Molecular Cell. 65 (4): 751–760.e4. doi:10.1016/j.molcel.2016.12.026. PMC 5321136. PMID 28132843.

[Sitron_Park_Brandman_pp._798–810-9] Sitron CS, Park JH, Brandman O (May 2017). "Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation". RNA. 23 (5). New York, N.Y.: 798–810. doi:10.1261/rna.060897.117. PMC 5393187. PMID 28223409.

[Matsuo_Ikeuchi_Saeki_Iwasaki_p.-10] Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, et al. (July 2017). "Ubiquitination of stalled ribosome triggers ribosome-associated quality control". Nature Communications. 8 (1) 159. Bibcode:2017NatCo...8..159M. doi:10.1038/s41467-017-00188-1. PMC 5534433. PMID 28757607.