ZNG1A

ZNG1A
Identifiers
Aliases	ZNG1A, COBP, COBW domain containing 1, CBWD1, Zn regulated GTPase metalloprotein activator 1A
External IDs	OMIM: 611078; MGI: 2385089; GeneCards: ZNG1A
Gene location (Human)
Chr.	Chromosome 9 (human)
End	179,147 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	24,938,974 bp
RNA expression pattern
	Top expressed in
	monocyte; ; body of pancreas; ; human kidney; ; left adrenal cortex; ; islet of Langerhans; ; right adrenal cortex; ; Achilles tendon; ; testicle; ; gastric mucosa; ; endometrium;
	Top expressed in
	spermatocyte; ; morula; ; spermatid; ; seminiferous tubule; ; tail of embryo; ; primitive streak; ; interventricular septum; ; lumbar spinal ganglion; ; muscle of thigh; ; embryo;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	55871
	226043
	ENSG00000172785
	ENSMUSG00000024878
	Q9BRT8
	Q8VEH6
	NM_001145355; NM_001145356; NM_018491
	NM_146097
	NP_001138827; NP_001138828; NP_060961
	NP_666209
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc-regulated GTPase metalloprotein activator 1A is a protein that in humans is encoded by the ZNG1A gene (previously CBWD1). Based on studies in mice, this protein functions to activate certain metalloproteins like METAP1 by directly transferring zinc to them.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172785 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024878 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wong A, Vallender EJ, Heretis K, Ilkin Y, Lahn BT, Martin CL, Ledbetter DH (Jul 2004). "Diverse fates of paralogs following segmental duplication of telomeric genes". Genomics. 84 (2): 239–47. doi:10.1016/j.ygeno.2004.03.001. PMID 15233989.
↑ Fan Y, Newman T, Linardopoulou E, Trask BJ (Nov 2002). "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions". Genome Res. 12 (11): 1663–72. doi:10.1101/gr.338402. PMC 187549. PMID 12421752.
↑ "Entrez Gene: CBWD1 COBW domain containing 1".
↑ "Zinc-regulated GTPase metalloprotein activator 1A". uniprot.org. UniProt consortium. Retrieved 2026-09-11.

External links

Human CBWD1 genome location and CBWD1 gene details page in the UCSC Genome Browser.

Page N, Butlin D, Manyonda I, Lowry P (2000). "The development of a genetic profile of placental gene expression during the first trimester of pregnancy: a potential tool for identifying novel secreted markers". Fetal Diagn. Ther. 15 (4): 237–45. doi:10.1159/000021014. PMID 10867487. S2CID 24233825.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Shi J, Cai W, Chen X, et al. (2001). "Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization". Brain Res. 910 (1–2): 29–37. doi:10.1016/S0006-8993(01)02393-9. PMID 11489251. S2CID 43814085.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000172785 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024878 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15233989-5] Wong A, Vallender EJ, Heretis K, Ilkin Y, Lahn BT, Martin CL, Ledbetter DH (Jul 2004). "Diverse fates of paralogs following segmental duplication of telomeric genes". Genomics. 84 (2): 239–47. doi:10.1016/j.ygeno.2004.03.001. PMID 15233989.

[pmid12421752-6] Fan Y, Newman T, Linardopoulou E, Trask BJ (Nov 2002). "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions". Genome Res. 12 (11): 1663–72. doi:10.1101/gr.338402. PMC 187549. PMID 12421752.

[entrez-7] "Entrez Gene: CBWD1 COBW domain containing 1".

[8] "Zinc-regulated GTPase metalloprotein activator 1A". uniprot.org. UniProt consortium. Retrieved 2026-09-11.

ZNG1A

References

External links

Further reading