Methionine aminopeptidase 1

METAP1
Identifiers
Aliases	METAP1, MAP1A, MetAP1A, methionyl aminopeptidase 1
External IDs	OMIM: 610151; MGI: 1922874; GeneCards: METAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B3H, 2B3K, 2B3L, 2G6P, 2GZ5, 2NQ6, 2NQ7, 4FLI, 4FLJ, 4FLK, 4FLL, 4HXX, 4IKR, 4IKS, 4IKT, 4IKU, 4IU6, 4U1B, 4U69, 4U6C, 4U6E, 4U6J, 4U6W, 4U6Z, 4U70, 4U71, 4U73, 4U75, 4U76
Enzyme activity
Gene location (Human)
Chr.	Chromosome 4 (human)
End	99,062,813 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	138,195,276 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; endometrium; ; Descending thoracic aorta; ; epithelium of nasopharynx; ; rectum; ; urinary bladder; ; gingival epithelium; ; hair follicle; ; oral cavity;
	Top expressed in
	primitive streak; ; lens; ; vastus lateralis muscle; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; hair follicle; ; crypt of lieberkuhn of small intestine; ; digastric muscle; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; aminopeptidase activity; metalloexopeptidase activity; hydrolase activity; metal ion binding;
Cellular component	cytosol; cytoplasm;
Biological process	peptidyl-methionine modification; platelet aggregation; N-terminal protein amino acid modification; regulation of translation; proteolysis; regulation of rhodopsin mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23173
	75624
	ENSG00000164024
	ENSMUSG00000005813
	P53582
	Q8BP48
	NM_015143
	NM_175224
	NP_055958
	NP_780433
	Wikidata
View/Edit Human	View/Edit Mouse

Methionine aminopeptidase 1 is an enzyme that in humans is encoded by the METAP1 gene. This enzyme is a methionyl aminopeptidase which cleaves the N-terminal methionine from precursor proteins, with particular affinity for when the second amino acid is small and non-charged. Also important for the normal functioning of the cell cycle. This enzyme uses metal cations as a cofactor (making it a metalloprotein), but which one is used in the body remains debated.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164024 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005813 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
↑ Dummitt B, Fei Y, Chang YH (Jul 2002). "Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae". Protein Pept Lett. 9 (4): 295–303. doi:10.2174/0929866023408607. PMID 12144506.
↑ "Entrez Gene: METAP1 methionyl aminopeptidase 1".
1 2 3 "Methionine aminopeptidase 1". uniprot.org. UniProt consortium. Retrieved 2026-09-11.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Methionine aminopeptidase 1

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164024 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005813 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7788527-5] Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.

[pmid12144506-6] Dummitt B, Fei Y, Chang YH (Jul 2002). "Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae". Protein Pept Lett. 9 (4): 295–303. doi:10.2174/0929866023408607. PMID 12144506.

[entrez-7] "Entrez Gene: METAP1 methionyl aminopeptidase 1".

[uniprot-8] 1 2 3 "Methionine aminopeptidase 1". uniprot.org. UniProt consortium. Retrieved 2026-09-11.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Methionine aminopeptidase 1

See also

References

Further reading

External links