DNPEP

DNPEP
Identifiers
Aliases	DNPEP, ASPEP, DAP, aspartyl aminopeptidase
External IDs	OMIM: 611367; MGI: 1278328; GeneCards: DNPEP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DYO
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	219,400,022 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	75,294,634 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; canal of the cervix; ; gastric mucosa; ; apex of heart; ; mucosa of transverse colon; ; right ovary; ; left uterine tube; ; upper lobe of left lung; ; ectocervix;
	Top expressed in
	intestinal villus; ; internal carotid artery; ; external carotid artery; ; Rostral migratory stream; ; epithelium of small intestine; ; aortic valve; ; ascending aorta; ; lobe of prostate; ; gastrula; ; endocardial cushion;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; zinc ion binding; aminopeptidase activity; protein binding; hydrolase activity; metallopeptidase activity; metal ion binding; metalloaminopeptidase activity; identical protein binding;
Cellular component	blood microparticle; nucleus; cytosol; cytoplasm; extracellular region;
Biological process	proteolysis; peptide metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23549
	13437
	ENSG00000123992
	ENSMUSG00000026209
	Q9ULA0
	Q9Z2W0
NM_012100; NM_001319116; NM_001319117; NM_001319118; NM_001319119;
	NM_001319120; NM_001319121; NM_001319122
	NM_001110831; NM_016878
NP_001306045; NP_001306046; NP_001306047; NP_001306048; NP_001306049;
	NP_001306050; NP_001306051; NP_036232; NP_001306050.1; NP_001306051.1
	NP_001104301; NP_058574
	Wikidata
View/Edit Human	View/Edit Mouse

Aspartyl aminopeptidase is an enzyme that in humans is encoded by the DNPEP gene.

Function

The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in the general metabolism of intracellular proteins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000123992 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026209 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wilk S, Wilk E, Magnusson RP (Jun 1998). "Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase". The Journal of Biological Chemistry. 273 (26): 15961–70. doi:10.1074/jbc.273.26.15961. PMID 9632644.
1 2 "Entrez Gene: DNPEP aspartyl aminopeptidase".

External links

The MEROPS online database for peptidases and their inhibitors: M18.002
PDBe-KB provides an overview of all the structure information available in the PDB for Human Aspartyl aminopeptidase (DNPEP)

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000123992 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026209 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9632644-5] Wilk S, Wilk E, Magnusson RP (Jun 1998). "Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase". The Journal of Biological Chemistry. 273 (26): 15961–70. doi:10.1074/jbc.273.26.15961. PMID 9632644.

[entrez-6] 1 2 "Entrez Gene: DNPEP aspartyl aminopeptidase".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

DNPEP

Function

References

Further reading

External links