Proteína 2 similar al retinoblastoma

RBL2
Estructuras disponibles
PDB	Búsqueda ortóloga: PDBe RCSB
Lista de codigos id de PDB
	4XI9, 5C1D
Identificadores
Alias	RBL2, P130, Rb2, retinoblastoma-like 2, RB transcriptional corepressor like 2, BRUWAG
IDs externos	OMIM: 180203 MGI: 105085 HomoloGene: 4098 GeneCards: RBL2
Ontología génica
Función molecular	• DNA binding; • GO:0001948, GO:0016582 unión a proteína plasmática; • promoter-specific chromatin binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific;
Componente celular	• nucléolo; • Exosoma (vesícula); • núcleo celular; • transcription regulator complex; • Nucleoplasma; • citosol; • cromatina;
Proceso biológico	• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • regulación del ciclo celular; • ciclo celular; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • regulation of lipid kinase activity; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • negative regulation of gene expression; • GO:1901227 negative regulation of transcription by RNA polymerase II; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • regulation of mitotic cell cycle; • diferenciación celular; • regulation of cell division; • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle;
	Fuentes: Amigo / QuickGO
Patrón de la expressión del ARN
	; ;
	Más referencias a datos de expressión
Ortólogos
	5934
	19651
	ENSG00000103479
	ENSMUSG00000031666
	Q08999
	Q64700
	NM_005611; NM_001323608; NM_001323609; NM_001323610; NM_001323611
	NM_001282000; NM_001282001; NM_011250
	NP_001310537; NP_001310538; NP_001310539; NP_001310540; NP_005602
	NP_001268929; NP_001268930; NP_035380
	Wikidata
Ver/Editar Humano	Ver/Editar Ratón

La proteína del retinoblastoma-like 2 (p130) es un factor de transcripción codificado en humanos por el gen rbl2. Esta proteína pertenece a la familia de proteínas bolsillo.

Interacciones

La proteína del retinoblastoma-like 2 ha demostrado ser capaz de interaccionar con:

Véase también

Familia de proteínas pocket

Referencias

↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
↑ Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (Sep de 1993). «Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain». Oncogene 8 (9): 2561-6. PMID 8361765.
↑ Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (Jul de 1996). «Genomic structure of the human retinoblastoma-related Rb2/p130 gene». Proc Natl Acad Sci U S A 93 (10): 4629-32. PMC 39329. PMID 8643454.
↑ Ferreira, R; Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep. de 1998). «The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (18): 10493-8. ISSN 0027-8424. PMID 9724731.
↑ Bouzahzah, B; Fu M, Iavarone A, Factor V M, Thorgeirsson S S, Pestell R G (Aug. de 2000). «Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo». Cancer Res. (UNITED STATES) 60 (16): 4531-7. ISSN 0008-5472. PMID 10969803.
↑ Wang, S; Ghosh R N, Chellappan S P (Dec. de 1998). «Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation». Mol. Cell. Biol. (UNITED STATES) 18 (12): 7487-98. ISSN 0270-7306. PMID 9819434.
↑ Meloni, A R; Smith E J, Nevins J R (Aug. de 1999). «A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574-9. ISSN 0027-8424. PMID 10449734.
↑ Fusco, C; Reymond A, Zervos A S (Aug. de 1998). «Molecular cloning and characterization of a novel retinoblastoma-binding protein». Genomics (UNITED STATES) 51 (3): 351-8. ISSN 0888-7543. PMID 9721205. doi:10.1006/geno.1998.5368.
1 2 Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (Feb. de 1999). «Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest». Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460-9. ISSN 0270-7306. PMID 9891079.
↑ Li, Y; Graham C, Lacy S, Duncan A M, Whyte P (Dec. de 1993). «The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E». Genes Dev. (UNITED STATES) 7 (12A): 2366-77. ISSN 0890-9369. PMID 8253383.
↑ Wang, S; Nath N; Adlam M; Chellappan S (Jun. de 1999). «Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function». Oncogene (ENGLAND) 18 (23): 3501-10. ISSN 0950-9232. PMID 10376528. doi:10.1038/sj.onc.1202684.
↑ Lacy, S; Whyte P (mayo. de 1997). «Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes». Oncogene (ENGLAND) 14 (20): 2395-406. ISSN 0950-9232. PMID 9188854. doi:10.1038/sj.onc.1201085.
↑ Sutcliffe, J E; Cairns C A, McLees A, Allison S J, Tosh K, White R J (Jun. de 1999). «RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130». Mol. Cell. Biol. (UNITED STATES) 19 (6): 4255-61. ISSN 0270-7306. PMID 10330166.
↑ Fan, S; Yuan R, Ma Y X, Xiong J, Meng Q, Erdos M, Zhao J N, Goldberg I D, Pestell R G, Rosen E M (Aug. de 2001). «Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding». Oncogene (England) 20 (35): 4827-41. ISSN 0950-9232. PMID 11521194. doi:10.1038/sj.onc.1204666.

Datos: Q18031061

[1] «Human PubMed Reference:».

[2] «Mouse PubMed Reference:».

[pmid8361765-3] Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (Sep de 1993). «Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain». Oncogene 8 (9): 2561-6. PMID 8361765.

[pmid8643454-4] Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (Jul de 1996). «Genomic structure of the human retinoblastoma-related Rb2/p130 gene». Proc Natl Acad Sci U S A 93 (10): 4629-32. PMC 39329. PMID 8643454.

[pmid9724731-5] Ferreira, R; Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep. de 1998). «The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (18): 10493-8. ISSN 0027-8424. PMID 9724731.

[pmid10969803-6] Bouzahzah, B; Fu M, Iavarone A, Factor V M, Thorgeirsson S S, Pestell R G (Aug. de 2000). «Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo». Cancer Res. (UNITED STATES) 60 (16): 4531-7. ISSN 0008-5472. PMID 10969803.

[pmid9819434-7] Wang, S; Ghosh R N, Chellappan S P (Dec. de 1998). «Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation». Mol. Cell. Biol. (UNITED STATES) 18 (12): 7487-98. ISSN 0270-7306. PMID 9819434.

[pmid10449734-8] Meloni, A R; Smith E J, Nevins J R (Aug. de 1999). «A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574-9. ISSN 0027-8424. PMID 10449734.

[pmid9721205-9] Fusco, C; Reymond A, Zervos A S (Aug. de 1998). «Molecular cloning and characterization of a novel retinoblastoma-binding protein». Genomics (UNITED STATES) 51 (3): 351-8. ISSN 0888-7543. PMID 9721205. doi:10.1006/geno.1998.5368.

[pmid9891079-10] 1 2 Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (Feb. de 1999). «Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest». Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460-9. ISSN 0270-7306. PMID 9891079.

[pmid8253383-11] Li, Y; Graham C, Lacy S, Duncan A M, Whyte P (Dec. de 1993). «The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E». Genes Dev. (UNITED STATES) 7 (12A): 2366-77. ISSN 0890-9369. PMID 8253383.

[pmid10376528-12] Wang, S; Nath N; Adlam M; Chellappan S (Jun. de 1999). «Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function». Oncogene (ENGLAND) 18 (23): 3501-10. ISSN 0950-9232. PMID 10376528. doi:10.1038/sj.onc.1202684.

[pmid9188854-13] Lacy, S; Whyte P (mayo. de 1997). «Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes». Oncogene (ENGLAND) 14 (20): 2395-406. ISSN 0950-9232. PMID 9188854. doi:10.1038/sj.onc.1201085.

[pmid10330166-14] Sutcliffe, J E; Cairns C A, McLees A, Allison S J, Tosh K, White R J (Jun. de 1999). «RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130». Mol. Cell. Biol. (UNITED STATES) 19 (6): 4255-61. ISSN 0270-7306. PMID 10330166.

[pmid11521194-15] Fan, S; Yuan R, Ma Y X, Xiong J, Meng Q, Erdos M, Zhao J N, Goldberg I D, Pestell R G, Rosen E M (Aug. de 2001). «Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding». Oncogene (England) 20 (35): 4827-41. ISSN 0950-9232. PMID 11521194. doi:10.1038/sj.onc.1204666.