TSLP

TSLP
	Visualisation de la protéine Cristallisée TSLP
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	4NN5, 4NN6, 4NN7
Identifiants
Alias	TSLP, Lymphopoïétine stromale thymique
IDs externes	OMIM: 607003 MGI: 1855696 HomoloGene: 81957 GeneCards: TSLP
Position du gène (humain)
Chr.	Chromosome 5 humain
Fin	111,078,026 bp
Position du gène (souris)
Chr.	Chromosome 18 (souris)
Fin	32,952,850 bp
Expression génique
	Fortement exprimé dans
	pancreatic epithelial cell; ; vésicule biliaire; ; cartilage tissue; ; right lobe of liver; ; ventricule droit; ; myocardium of left ventricle; ; apex of heart; ; vessie; ; prostate; ; artère coronaire droite;
	Fortement exprimé dans
	embryon; ; embryon; ; left lung lobe; ; endothelial cell of lymphatic vessel; ; zygote; ; cellule de Paneth; ; poumon droit; ; lobe pulmonaire droit; ; secondary oocyte; ; valve auriculo-ventriculaire;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	cytokine activity; interleukin-7 receptor binding;
Composant cellulaire	milieu extracellulaire; région extracellulaire;
Processus biologique	regulation of signaling receptor activity; interleukin-7-mediated signaling pathway; positive regulation of cytokine-mediated signaling pathway; positive regulation of cell population proliferation; positive regulation of chemokine production; positive regulation of interleukin-10 production; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of interleukin-6 production; positive regulation of mast cell activation; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of apoptotic process; positive regulation of inflammatory response; defense response to Gram-negative bacterium; defense response to fungus; antimicrobial humoral immune response mediated by antimicrobial peptide; positive regulation of chemokine (C-C motif) ligand 1 production; positive regulation of granulocyte colony-stimulating factor production; positive regulation of receptor signaling pathway via STAT;
	Sources:Amigo / QuickGO
Orthologues
	85480
	53603
	ENSG00000145777
	ENSMUSG00000024379
	Q969D9
	Q9JIE6
	NM_033035; NM_138551
	NM_021367
	NP_149024; NP_612561
	NP_067342
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

La lymphopoïétine stromale thymique (en anglais, Thymic stromal lymphopoietin [TSLP]) est une cytokine.

Rôles

Elle est exprimée par les cellules épithéliales et joue un rôle dans l'inflammation d'origine allergique en stimulant les cellules dendritiques des monocytes et des lymphocytes T auxiliaires. Sa sécrétion est stimulée par une infection, un traumatisme ou une inflammation.

Son expression est augmentée dans les voies aériennes des asthmatiques et serait un signe de gravité de la maladie. Sa concentration est augmentée dans le mucus bronchique des bronchitiques et des asthmatiques.

Dans la peau, elle joue un rôle protecteur contre les cancers. Sa synthèse est augmentée par la vitamine D, ce qui entraîne une diminution du risque de kératose actinique, une atteinte de la peau pouvant évoluer en cancer.

Génétique

Une mutation proche du site du gène TSLP, situé sur le chromosome 5 humain, serait associée à l'asthme^,.

Cible thérapeutique

Le tézépelumab est un anticorps monoclonal dirigé contre la TSLP. Son administration réduit la bronchoconstriction d'origine allergique et l'inflammation des bronches.

Notes et références

1 2 3 GRCh38: Ensembl release 89: ENSG00000145777 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024379 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Soumelis V, Reche PA, Kanzler H et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP, Nat Immunol, 2002;3:673-680
↑ Reche PA, Soumelis V, Gorman DM et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells, J Immunol, 2001;167:336-343
↑ Ziegler SF, Artis D, Sensing the outside world: TSLP regulates barrier immunity, Nat Immunol, 2010;11:289–293
↑ Allakhverdi Z, Comeau MR, Jessup HK et al. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells, J Exp Med, 2007;204:253-258
↑ Ying S, O'Connor B, Ratoff J et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity, J Immunol, 2005;174:8183-8190
↑ Ying S, O'Connor B, Ratoff J et al. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease, J Immunol, 2008;181:2790-2798
↑ Demehri S, Turkoz A, Manivasagam S, Yockey LJ, Turkoz M, Kopan R, Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin, Cancer Cell, 2012;22:494–505
↑ Sato-Deguchi E, Imafuku S, Chou B, Ishii K, Hiromatsu K, Nakayama J, Topical vitamin D(3) analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions, Br J Dermatol, 2012;167:77–84
↑ Cunningham TJ, Tabacchi M, Eliane JP et al. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy, J Clin Invest, 2017;127:106-116
↑ He JQ, Hallstrand TS, Knight D et al. A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness, J Allergy Clin Immunol, 2009;124:222-229
↑ Harada M, Hirota T, Jodo AI et al. Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma, Am J Respir Cell Mol Biol, 2011;44:787-793
↑ Gauvreau PM, Boulet LP, Gauvreau GM, O'Byrneet al. Effects of an anti-TSLP antibody on allergen-induced asthmatic responses, N Eng J Med, 2014;370:2102-2110

Portail de la médecine

Portail de la biologie cellulaire et moléculaire

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000145777 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024379 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Soumelis_2002-5] Soumelis V, Reche PA, Kanzler H et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP, Nat Immunol, 2002;3:673-680

[Reche_2001-6] Reche PA, Soumelis V, Gorman DM et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells, J Immunol, 2001;167:336-343

[Ziegler_2010-7] Ziegler SF, Artis D, Sensing the outside world: TSLP regulates barrier immunity, Nat Immunol, 2010;11:289–293

[Allakhverdi_2007-8] Allakhverdi Z, Comeau MR, Jessup HK et al. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells, J Exp Med, 2007;204:253-258

[Ying_2005-9] Ying S, O'Connor B, Ratoff J et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity, J Immunol, 2005;174:8183-8190

[Ying_2008-10] Ying S, O'Connor B, Ratoff J et al. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease, J Immunol, 2008;181:2790-2798

[Demehri_2012-11] Demehri S, Turkoz A, Manivasagam S, Yockey LJ, Turkoz M, Kopan R, Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin, Cancer Cell, 2012;22:494–505

[Sato-Deguchi_2012-12] Sato-Deguchi E, Imafuku S, Chou B, Ishii K, Hiromatsu K, Nakayama J, Topical vitamin D(3) analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions, Br J Dermatol, 2012;167:77–84

[Cunningham_2017-13] Cunningham TJ, Tabacchi M, Eliane JP et al. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy, J Clin Invest, 2017;127:106-116

[He_2009-14] He JQ, Hallstrand TS, Knight D et al. A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness, J Allergy Clin Immunol, 2009;124:222-229

[Harada_2011-15] Harada M, Hirota T, Jodo AI et al. Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma, Am J Respir Cell Mol Biol, 2011;44:787-793

[Gauvreau_2014-16] Gauvreau PM, Boulet LP, Gauvreau GM, O'Byrneet al. Effects of an anti-TSLP antibody on allergen-induced asthmatic responses, N Eng J Med, 2014;370:2102-2110