ヤヌスキナーゼ1

JAK1
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8, 5IXD, 5IXI
識別子
記号	JAK1, JAK1A, JAK1B, JTK3, Janus kinase 1, AIIDE
外部ID	OMIM: 147795 MGI: 96628 HomoloGene: 1678 GeneCards: JAK1
EC番号	2.7.10.2
遺伝子の位置 (ヒト)
染色体	1番染色体 (ヒト)
終点	65,067,754 bp
遺伝子の位置 (マウス)
染色体	4番染色体 (マウス)
終点	101,265,282 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• トランスフェラーゼ活性; • ヌクレオチド結合; • protein kinase activity; • CCR5 chemokine receptor binding; • growth hormone receptor binding; • 金属イオン結合; • キナーゼ活性; • 血漿タンパク結合; • protein tyrosine kinase activity; • protein phosphatase binding; • 受容体結合; • ATP binding; • ubiquitin protein ligase binding; • non-membrane spanning protein tyrosine kinase activity;
細胞の構成要素	• 細胞質; • 細胞質基質; • 膜; • 焦点接着; • extrinsic component of cytoplasmic side of plasma membrane; • 細胞骨格; • 細胞内膜系; • 細胞核; • エンドソーム;
生物学的プロセス	• 細胞分化; • intracellular signal transduction; • リン酸化; • transmembrane receptor protein tyrosine kinase signaling pathway; • interferon-gamma-mediated signaling pathway; • response to antibiotic; • MAPK cascade; • positive regulation of sprouting angiogenesis; • タンパク質リン酸化; • regulation of type I interferon-mediated signaling pathway; • regulation of interferon-gamma-mediated signaling pathway; • regulation of cell population proliferation; • type I interferon signaling pathway; • interleukin-2-mediated signaling pathway; • peptidyl-tyrosine autophosphorylation; • 自己リン酸化; • 遊走; • 自然免疫; • interleukin-12-mediated signaling pathway; • interleukin-7-mediated signaling pathway; • interleukin-15-mediated signaling pathway; • interleukin-9-mediated signaling pathway; • 分子機能制御; • peptidyl-tyrosine phosphorylation; • サイトカイン媒介シグナル伝達経路; • interleukin-21-mediated signaling pathway; • interleukin-6-mediated signaling pathway; • interleukin-27-mediated signaling pathway; • interleukin-35-mediated signaling pathway;
	出典:Amigo / QuickGO
オルソログ
	3716
	16451
	ENSG00000162434
	ENSMUSG00000028530
	P23458
	P52332
NM_002227; NM_001320923; NM_001321852; NM_001321853; NM_001321854;
	NM_001321855; NM_001321856; NM_001321857
	NM_146145; NM_013567
NP_001307852; NP_001308781; NP_001308782; NP_001308783; NP_001308784;
	NP_001308785; NP_001308786; NP_002218
	n/a
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

ヤヌスキナーゼ1（英: Janus kinase 1、JAK1）は、ヤヌスキナーゼファミリーに属するチロシンキナーゼ（英語版）であり、特定のI・II型サイトカインのシグナル伝達に必要不可欠である。JAK1はI型サイトカイン受容体（英語版）の共通γ鎖（γc）と相互作用し、IL-2受容体ファミリー（IL-2R、IL-7R（英語版）、IL-9R（英語版）、IL-15R）、IL-4受容体ファミリー（IL-4R（英語版）、IL-13R（英語版））、gp130（英語版）受容体ファミリー（IL-6R（英語版）、IL-11R（英語版）、LIF-R（英語版）、OSM-R（英語版）、CT-1（英語版）R、CNTF-R（英語版）、Leptin-R（英語版））からのシグナルを発する。またJAK1はII型サイトカイン受容体（英語版）を介し、I型・II型インターフェロンやIL-10ファミリー（英語版）のシグナルの伝達にも重要である。マウスでは、Jak1の喪失はおそらく哺乳の困難のために新生児致死となる。がん細胞におけるJAK1の発現は個々の細胞の収縮を可能にし、腫瘍を離れ、体内の他の部位への転移をもたらしている可能性がある。

相互作用

JAK1は次に挙げる因子と相互作用することが示されている。

出典

1 2 3 GRCh38: Ensembl release 89: ENSG00000162434 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028530 - Ensembl, May 2017
↑ Human PubMed Reference:
↑ Mouse PubMed Reference:
↑ Gadina M, Hilton D, Johnston JA, Morinobu A, Lighvani A, Zhou YJ, Visconti R, O'Shea JJ (2001). “Signaling by type I and II cytokine receptors: ten years after”. Curr. Opin. Immunol. 13 (3): 363–73. doi:10.1016/S0952-7915(00)00228-4. PMID 11406370. https://zenodo.org/record/1260155.
↑ Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, King KL, Sheehan KC, Yin L, Pennica D, Johnson EM, Schreiber RD (1998). “Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses”. Cell 93 (3): 373–83. doi:10.1016/S0092-8674(00)81166-6. PMID 9590172.
↑ Christian Nordqvist. “Protein JAK Makes Cancer Cells Contract, So They Can Squeeze Out Of A Tumor”. Medical News Today.
↑ Collum RG, Brutsaert S, Lee G, Schindler C (August 2000). “A Stat3-interacting protein (StIP1) regulates cytokine signal transduction”. Proc. Natl. Acad. Sci. U.S.A. 97 (18): 10120–5. Bibcode:2000PNAS...9710120C. doi:10.1073/pnas.170192197. PMC 27739. PMID 10954736.
↑ Usacheva A, Tian X, Sandoval R, Salvi D, Levy D, Colamonici OR (September 2003). “The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex”. J. Immunol. 171 (6): 2989–94. doi:10.4049/jimmunol.171.6.2989. PMID 12960323.
↑ Haan C, Is'harc H, Hermanns HM, Schmitz-Van De Leur H, Kerr IM, Heinrich PC, Grötzinger J, Behrmann I (October 2001). “Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction”. J. Biol. Chem. 276 (40): 37451–8. doi:10.1074/jbc.M106135200. PMID 11468294.
↑ Kim H, Baumann H (December 1997). “Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells”. J. Biol. Chem. 272 (49): 30741–7. doi:10.1074/jbc.272.49.30741. PMID 9388212.
↑ Haan C, Heinrich PC, Behrmann I (January 2002). “Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation”. Biochem. J. 361 (Pt 1): 105–11. doi:10.1042/0264-6021:3610105. PMC 1222284. PMID 11742534.
↑ Kim H, Lee YH, Won J, Yun Y (September 2001). “Through induction of juxtaposition and tyrosine kinase activity of Jak1, X-gene product of hepatitis B virus stimulates Ras and the transcriptional activation through AP-1, NF-kappaB, and SRE enhancers”. Biochem. Biophys. Res. Commun. 286 (5): 886–94. Bibcode:2001BBRC..286..886K. doi:10.1006/bbrc.2001.5496. PMID 11527382.
↑ Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E (December 1995). “Involvement of Janus kinases in the insulin signaling pathway”. Eur. J. Biochem. 234 (2): 656–60. doi:10.1111/j.1432-1033.1995.656_b.x. PMID 8536716.
1 2 Usacheva A, Kotenko S, Witte MM, Colamonici OR (August 2002). “Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors”. J. Immunol. 169 (3): 1302–8. doi:10.4049/jimmunol.169.3.1302. PMID 12133952.
↑ Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). “Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits”. Science 266 (5187): 1045–7. Bibcode:1994Sci...266.1045M. doi:10.1126/science.7973659. PMID 7973659.
↑ Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O (November 1994). “Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID”. Science 266 (5187): 1042–5. Bibcode:1994Sci...266.1042R. doi:10.1126/science.7973658. PMID 7973658. https://zenodo.org/record/1231239.
↑ Zhu MH, Berry JA, Russell SM, Leonard WJ (April 1998). “Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta”. J. Biol. Chem. 273 (17): 10719–25. doi:10.1074/jbc.273.17.10719. PMID 9553136.
↑ Migone TS, Rodig S, Cacalano NA, Berg M, Schreiber RD, Leonard WJ (November 1998). “Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation”. Mol. Cell. Biol. 18 (11): 6416–22. doi:10.1128/mcb.18.11.6416. PMC 109227. PMID 9774657.
↑ Gual P, Baron V, Lequoy V, Van Obberghen E (March 1998). “Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor”. Endocrinology 139 (3): 884–93. doi:10.1210/endo.139.3.5829. PMID 9492017.
↑ Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ (December 1995). “Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases”. J. Biol. Chem. 270 (48): 28527–30. doi:10.1074/jbc.270.48.28527. PMID 7499365.
↑ Usacheva A, Sandoval R, Domanski P, Kotenko SV, Nelms K, Goldsmith MA, Colamonici OR (December 2002). “Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation”. J. Biol. Chem. 277 (50): 48220–6. doi:10.1074/jbc.M205757200. PMID 12374810.
↑ Yin T, Shen R, Feng GS, Yang YC (January 1997). “Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases”. J. Biol. Chem. 272 (2): 1032–7. doi:10.1074/jbc.272.2.1032. PMID 8995399.
↑ Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F (January 2003). “SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130”. J. Biol. Chem. 278 (1): 661–71. doi:10.1074/jbc.M210552200. PMID 12403768.
↑ Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF (December 2000). “Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways”. J. Biol. Chem. 275 (49): 38633–9. doi:10.1074/jbc.M007849200. PMID 10993906.
↑ Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K (July 2000). “STAM2, a new member of the STAM family, binding to the Janus kinases”. FEBS Lett. 477 (1–2): 55–61. Bibcode:2000FEBSL.477...55E. doi:10.1016/s0014-5793(00)01760-9. PMID 10899310.
↑ Ueda T, Bruchovsky N, Sadar MD (March 2002). “Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways”. J. Biol. Chem. 277 (9): 7076–85. doi:10.1074/jbc.M108255200. PMID 11751884.
↑ Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F (August 2001). “Constitutive activation of STAT transcription factors in acute myelogenous leukemia”. Eur. J. Haematol. 67 (2): 63–71. doi:10.1034/j.1600-0609.2001.t01-1-00385.x. PMID 11722592.
1 2 Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (February 1997). “An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT”. Oncogene 14 (7): 751–61. doi:10.1038/sj.onc.1200907. PMID 9047382.
↑ Guo D, Dunbar JD, Yang CH, Pfeffer LM, Donner DB (March 1998). “Induction of Jak/STAT signaling by activation of the type 1 TNF receptor”. J. Immunol. 160 (6): 2742–50. doi:10.4049/jimmunol.160.6.2742. PMID 9510175.
↑ Miscia S, Marchisio M, Grilli A, Di Valerio V, Centurione L, Sabatino G, Garaci F, Zauli G, Bonvini E, Di Baldassarre A (January 2002). “Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells”. Cell Growth Differ. 13 (1): 13–8. PMID 11801527.

外部リンク

Janus Kinase 1 - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）

この項目は、生物学に関連した書きかけの項目です。この項目を加筆・訂正などしてくださる協力者を求めています（プロジェクト:生命科学／Portal:生物学）。

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162434 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028530 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid11406370-5] Gadina M, Hilton D, Johnston JA, Morinobu A, Lighvani A, Zhou YJ, Visconti R, O'Shea JJ (2001). “Signaling by type I and II cytokine receptors: ten years after”. Curr. Opin. Immunol. 13 (3): 363–73. doi:10.1016/S0952-7915(00)00228-4. PMID 11406370. https://zenodo.org/record/1260155.

[pmid9590172-6] Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, King KL, Sheehan KC, Yin L, Pennica D, Johnson EM, Schreiber RD (1998). “Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses”. Cell 93 (3): 373–83. doi:10.1016/S0092-8674(00)81166-6. PMID 9590172.

[7] Christian Nordqvist. “Protein JAK Makes Cancer Cells Contract, So They Can Squeeze Out Of A Tumor”. Medical News Today.

[pmid10954736-8] Collum RG, Brutsaert S, Lee G, Schindler C (August 2000). “A Stat3-interacting protein (StIP1) regulates cytokine signal transduction”. Proc. Natl. Acad. Sci. U.S.A. 97 (18): 10120–5. Bibcode:2000PNAS...9710120C. doi:10.1073/pnas.170192197. PMC 27739. PMID 10954736.

[pmid12960323-9] Usacheva A, Tian X, Sandoval R, Salvi D, Levy D, Colamonici OR (September 2003). “The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex”. J. Immunol. 171 (6): 2989–94. doi:10.4049/jimmunol.171.6.2989. PMID 12960323.

[pmid11468294-10] Haan C, Is'harc H, Hermanns HM, Schmitz-Van De Leur H, Kerr IM, Heinrich PC, Grötzinger J, Behrmann I (October 2001). “Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction”. J. Biol. Chem. 276 (40): 37451–8. doi:10.1074/jbc.M106135200. PMID 11468294.

[pmid9388212-11] Kim H, Baumann H (December 1997). “Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells”. J. Biol. Chem. 272 (49): 30741–7. doi:10.1074/jbc.272.49.30741. PMID 9388212.

[pmid11742534-12] Haan C, Heinrich PC, Behrmann I (January 2002). “Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation”. Biochem. J. 361 (Pt 1): 105–11. doi:10.1042/0264-6021:3610105. PMC 1222284. PMID 11742534.

[pmid11527382-13] Kim H, Lee YH, Won J, Yun Y (September 2001). “Through induction of juxtaposition and tyrosine kinase activity of Jak1, X-gene product of hepatitis B virus stimulates Ras and the transcriptional activation through AP-1, NF-kappaB, and SRE enhancers”. Biochem. Biophys. Res. Commun. 286 (5): 886–94. Bibcode:2001BBRC..286..886K. doi:10.1006/bbrc.2001.5496. PMID 11527382.

[pmid8536716-14] Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E (December 1995). “Involvement of Janus kinases in the insulin signaling pathway”. Eur. J. Biochem. 234 (2): 656–60. doi:10.1111/j.1432-1033.1995.656_b.x. PMID 8536716.

[pmid12133952-15] 1 2 Usacheva A, Kotenko S, Witte MM, Colamonici OR (August 2002). “Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors”. J. Immunol. 169 (3): 1302–8. doi:10.4049/jimmunol.169.3.1302. PMID 12133952.

[pmid7973659-16] Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). “Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits”. Science 266 (5187): 1045–7. Bibcode:1994Sci...266.1045M. doi:10.1126/science.7973659. PMID 7973659.

[pmid7973658-17] Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O (November 1994). “Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID”. Science 266 (5187): 1042–5. Bibcode:1994Sci...266.1042R. doi:10.1126/science.7973658. PMID 7973658. https://zenodo.org/record/1231239.

[pmid9553136-18] Zhu MH, Berry JA, Russell SM, Leonard WJ (April 1998). “Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta”. J. Biol. Chem. 273 (17): 10719–25. doi:10.1074/jbc.273.17.10719. PMID 9553136.

[pmid9774657-19] Migone TS, Rodig S, Cacalano NA, Berg M, Schreiber RD, Leonard WJ (November 1998). “Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation”. Mol. Cell. Biol. 18 (11): 6416–22. doi:10.1128/mcb.18.11.6416. PMC 109227. PMID 9774657.

[pmid9492017-20] Gual P, Baron V, Lequoy V, Van Obberghen E (March 1998). “Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor”. Endocrinology 139 (3): 884–93. doi:10.1210/endo.139.3.5829. PMID 9492017.

[pmid7499365-21] Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ (December 1995). “Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases”. J. Biol. Chem. 270 (48): 28527–30. doi:10.1074/jbc.270.48.28527. PMID 7499365.

[pmid12374810-22] Usacheva A, Sandoval R, Domanski P, Kotenko SV, Nelms K, Goldsmith MA, Colamonici OR (December 2002). “Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation”. J. Biol. Chem. 277 (50): 48220–6. doi:10.1074/jbc.M205757200. PMID 12374810.

[pmid8995399-23] Yin T, Shen R, Feng GS, Yang YC (January 1997). “Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases”. J. Biol. Chem. 272 (2): 1032–7. doi:10.1074/jbc.272.2.1032. PMID 8995399.

[pmid12403768-24] Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F (January 2003). “SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130”. J. Biol. Chem. 278 (1): 661–71. doi:10.1074/jbc.M210552200. PMID 12403768.

[pmid10993906-25] Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF (December 2000). “Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways”. J. Biol. Chem. 275 (49): 38633–9. doi:10.1074/jbc.M007849200. PMID 10993906.

[pmid10899310-26] Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K (July 2000). “STAM2, a new member of the STAM family, binding to the Janus kinases”. FEBS Lett. 477 (1–2): 55–61. Bibcode:2000FEBSL.477...55E. doi:10.1016/s0014-5793(00)01760-9. PMID 10899310.

[pmid11751884-27] Ueda T, Bruchovsky N, Sadar MD (March 2002). “Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways”. J. Biol. Chem. 277 (9): 7076–85. doi:10.1074/jbc.M108255200. PMID 11751884.

[pmid11722592-28] Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F (August 2001). “Constitutive activation of STAT transcription factors in acute myelogenous leukemia”. Eur. J. Haematol. 67 (2): 63–71. doi:10.1034/j.1600-0609.2001.t01-1-00385.x. PMID 11722592.

[pmid9047382-29] 1 2 Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (February 1997). “An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT”. Oncogene 14 (7): 751–61. doi:10.1038/sj.onc.1200907. PMID 9047382.

[pmid9510175-30] Guo D, Dunbar JD, Yang CH, Pfeffer LM, Donner DB (March 1998). “Induction of Jak/STAT signaling by activation of the type 1 TNF receptor”. J. Immunol. 160 (6): 2742–50. doi:10.4049/jimmunol.160.6.2742. PMID 9510175.

[pmid11801527-31] Miscia S, Marchisio M, Grilli A, Di Valerio V, Centurione L, Sabatino G, Garaci F, Zauli G, Bonvini E, Di Baldassarre A (January 2002). “Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells”. Cell Growth Differ. 13 (1): 13–8. PMID 11801527.

ヤヌスキナーゼ1

相互作用

出典

関連文献

関連項目

外部リンク