Teams and riders
| Entrant | Constructor | Chassis | Race rider | |
|---|---|---|---|---|
| No. | rider name | |||
 Aprilia Racing |
Aprilla | RS GP | 12 |  Maverick Viñales |
| 41 | Aleix Espargaró | |||
 CryptoData RNF MotoGP Team |
25 | Raúl Fernández | ||
| 32 | Lorenzo Savadori | |||
| 88 |  Miguel Oliveira | |||
| Ducati Lenovo Team |
Ducati | Desmosedici GP23 | 1 | Francesco Bagnaia |
| 9 | Danilo Petrucci | |||
| 23 | Enea Bastianini | |||
| 51 | Michele Pirro | |||
| Prima Pramac Racing |
5 |  Johann Zarco | ||
| 89 | Jorge Martín | |||
| Gresini Racing MotoGP |
Desmosedici GP22 | 49 | Fabio Di Giannantonio | |
| 73 | Álex Márquez | |||
| Mooney VR46 Racing Team |
10 | Luca Marini | ||
| 72 | Marco Bezzecchi | |||
 LCR Honda Castrol |
Honda | RC213V | 6 |  Stefan Bradl |
| 27 | Iker Lecuona | |||
| 42 | Álex Rins | |||
| LCR Honda Idemitsu |
30 |  Takaaki Nakagami | ||
| Respol Honda Team |
6 | Stefan Bradl | ||
| 27 | Iker Lecuona | |||
| 36 | Joan Mir | |||
| 93 | Marc Márquez | |||
| GasGas Factory Racing Tech3 |
KTM | RC16 | 37 | Augusto Fernández |
| 44 | Pol Espargaró | |||
| 94 | Jonas Folger | |||
 Red Bull KTM Factory Racing |
33 |  Brad Binder | ||
| 43 |  Jack Miller | |||
| Monster Energy Yamaha MotoGP |
Yamaha | YZR-M1 | 20 | Fabio Quartararo |
| 21 | Franco Morbidelli | |||
All teams use series-specified Michelin tyres.
Team changes
- RNF Racing switched to Aprilia after a season with Yamaha.
- Suzuki withdrew from the MotoGP class at the end of the 2022 season.
- Tech3 KTM Factory Racing were rebranded as GasGas Factory Racing Tech3. The team used KTM bikes. Tech3 continued to own and operate the team.
Rider changes
- Jack Miller moved to the KTM factory team from the Ducati factory team, replacing Miguel Oliveira. Oliveira then moved to RNF Aprilia MotoGP Team.
- Álex Márquez moved to Gresini Racing MotoGP from LCR Honda, replacing Enea Bastianini. Bastianini was then promoted to the Ducati factory team, replacing Jack Miller.
- Álex Rins moved to LCR Honda from the now defunct Suzuki MotoGP team, replacing Álex Márquez.
- Pol Espargaró moved to the newly rebranded GasGas Factory Racing team from the Honda factory team. He was replaced by Joan Mir, who moved from the now defunct Suzuki MotoGP team.
- Raúl Fernández moved to RNF Aprilia MotoGP Team from Tech3 KTM Factory Racing.
- Remy Gardner left MotoGP for the Superbike World Championship. He was replaced by 2022 Moto2 World Championship Moto2 World Riders' Champion Augusto Fernández, who entered the MotoGP class with the rebranded GasGas Factory Racing team.
- After being left without a place in the MotoGP grid, Darryn Binder went down to Moto2 to make his debut in that class.
Mid-season changes
- Pol Espargaró missed seven Grands Prix starting from the Argentine round after suffering numerous injuries during P2 of the Portuguese round. He was not replaced for the Argentine round, but was replaced starting from the Americas round by Jonas Folger.
- Enea Bastianini missed the Argentine and Americas rounds after suffering a fractured right collarbone due to a collision with Luca Marini in the sprint of the Portuguese round. He was not replaced for the Argentine round, and was replaced for the Americas round by Michele Pirro. Bastianini also missed the French round after a failed return in the Spanish round which saw him withdraw from the race after P2 due to continuous shoulder pain. He was replaced by Danilo Petrucci. Bastianini will also miss the San Marino, Indian, and Japanese rounds after undergoing surgery on his fractured left ankle and left hand that were sustained during the Catalan race. He was not replaced for the San Marino round, and by Pirro again for the Indian round.
- Marc Márquez missed several races after suffering a broken first metacarpal due to a collision with Miguel Oliveira during the main race of the Portuguese round. He was not replaced for the Argentine round, replaced by Stefan Bradl for the Americas round, and was replaced by Iker Lecuona for the Spanish round.
- Miguel Oliveira missed the Argentine round due to the aforementioned collision with Márquez during the main race of the previous Portuguese round. Oliveira was declared unfit after further testing and was not replaced. Oliveira also missed the French round after he sustained a shoulder injury after a collision with Fabio Quartararo during the previous Spanish round and was replaced by Lorenzo Savadori. He will also miss the Valencian round after suffering a fractured scapula during the sprint of the Qatar round.
- Joan Mir missed the German and Dutch rounds after suffering a right hand injury during P2 of the previous Italian round. He was not replaced for the German round, but was replaced by Iker Lecuona for the Dutch round.
- Álex Rins missed six Grands Prix starting from the German round after undergoing surgery on a broken right leg that was sustained during the sprint of the Italian round. He was not replaced for the German round, but was replaced by Stefan Bradl for the Dutch round. He was not replaced for the German round, but was replaced by Stefan Bradl for the Dutch and Indian rounds, by Iker Lecuona for the British, Austrian, and Catalan rounds. He competed during Friday practice sessions for the Japanese round, before being replaced by Bradl after he was declared unfit for the rest of the weekend. Rins also missed the Thailand round after having surgery on a hernia on his leg previously broken during the Italian round. He was not replaced, and by Lecuona again for the Malaysian and Qatar rounds.
- Álex Márquez missed the Japanese round after suffering a triple rib fracture during Q1 of the previous Indian round. He was not replaced.
- Luca Marini missed the Japanese round after suffering a fractured left collarbone during the sprint of the previous Indian round. He was not replaced.
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