January 24 – Commissioners from Scotland and England meet at Richmond Palace in London to finalize an agreement on the marriage between Scotland's King James IV to the daughter of England's King Henry VII, the princess Margaret Tudor, with a dowry of 35,000 Scottish Punnds and an agreement for a "treaty of perpetual peace". The marriage will be completed by proxy on January 25, 1503.
April 2 – Arthur, Prince of Wales, the 15-year-old Duke of Cornwall and Earl of Chester, heir to the English throne as eldest son of King Henry VII, dies after a long illness less than five months after marrying Catherine of Aragon. Arthur's 10-year-old brother, Henry, Duke of York, becomes the new heir to the throne and will later succeed his father as King Henry VIII.
April 14 – The formal coronation of Ivan the Great as Grand Prince of Moscow (encompassing most of the Russian people's territory) to reflect that he is the nation's sole ruler. Ivan had been co-ruler of Moscow from 1449 to 1462, ruler from 1462 to 1471 and 1490 to 1498, and co-ruler with his eldest son (Ivan the Young, 1471-1490) and his grandson, Dmitry Ivanovich from 1498 onward.
May 9 – Christopher Columbus leaves Cadiz in Spain for his fourth and final trip to the New World, taking with him 147 men on his flagship, Capitana and the companion ships Gallega, Vizcaína, and Santiago de Palos. He explores Central America, and discovers the Isthmus of Panama and the land now occupied by Honduras, and Costa Rica, and possibly the island of St. Lucia as well
May 26 – Columbus and his men complete the rescue of stranded Portuguese soldiers in Morocco, then depart Asilah for a crossing of the Atlantic in 20 days.
June 29 – Columbus and his crew attempt to land at Santo Domingo in order to avoid being caught in a hurricane, despite being ordered not to return to Hispaniola. Nicolás de Ovando, the Spanish Viceroy, refuses to let Columbus sail into harbor and does not believe the warnings of the hurricane, which strikes two days later.
July–September
July 1 – A powerful hurricane sweeps through the Caribbean Sea near Puerto Rico and the island of Hispaniola, two days after Christopher Columbus was denied permission to land at Santo Domingo. An estimated 500 people are killed when the winds wreck 20 of the 31 ships brought from Spain by the new Viceroy, Nicolás de Ovando, including Ovando's flagship, El Dorado. Former Viceroy Francisco de Bobadilla and administrator Francisco Roldán are among the people killed. A ship provided by Bobadilla for Columbus to transport the gold owed to him, the Aguja, is one of the 11 to survive the hurricane and accusations are made that Columbus magically invoked the storm as an act of vengeance.
July 28 – At Augsburg, Maximilian I, Germany's King of the Romans signs a treaty with representatives of King Henry VII of England, agreeing not to provide assistance to English rebels.
July 30 – The first encounter between Europeans and the Maya people of Central America takes place when the Columbus brothers anchor at Guanaja, one of the Bay Islands off of the coast of what is now the nation of Honduras. An unfortunate group of Mayan traders happens to arrive at Guanaja at the same time, and its cargo is looted by Bartolomeo Columbus and his crew.
December 31 – Cesare Borgia (son of Pope Alexander VI) occupies Urbino, where he imprisons two potentially treacherous allies, Vitellozzo and Oliveretto; he executes them the next morning.
