3-phytase

3-phytase
Identifiers
EC no.3.1.3.8
CAS no.37288-11-2
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme 3-phytase (EC 3.1.3.8) catalyzes the reaction

2D representation of the chemical structure of phytic acid .
phytic acid
 
H2O
Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right
 
 
 
2D representation of the chemical structure of inositol pentakisphosphate .
inositol pentakisphosphate

The enzyme characterised from Aspergillus ficuum hydrolyses phytic acid to inositol pentakisphosphate and orthophosphate. A genetically modified form of the enzyme has been evaluated for its safety in food manufacture.

These enzymes belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name myo-inositol-hexakisphosphate 3-phosphohydrolase. Other names in common use include 1-phytase, phytate 1-phosphatase, phytate 3-phosphatase, and phytate 6-phosphatase.

Enzymes of this type participate in inositol phosphate metabolism.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1CVM​, PDB: 1IHP​, PDB: 1POO​, PDB: 1QFX​, PDB: 1QLG​, PDB: 1QWO​, PDB: 1SK8​, PDB: 1SK9​, PDB: 1SKA​, PDB: 1SKB​, PDB: 2GFI​, and PDB: 2POO​.

See also

References

  1. ↑ Irving, G. C. J.; Cosgrove, D. J. (1972). "Inositol Phosphate Phosphatases of Microbiological Origin: The Inositol Pentaphosphate Products of Aspergillus ficuum Phytases". Journal of Bacteriology. 112 (1): 434–438. doi:10.1128/JB.112.1.434-438.1972. PMC 251429. PMID 4342816.
  2. ↑ Mullaney EJ, Ullah AH (December 2003). "The term phytase comprises several different classes of enzymes". Biochemical and Biophysical Research Communications. 312 (1): 179–84. Bibcode:2003BBRC..312..179M. doi:10.1016/j.bbrc.2003.09.176. PMID 14630039.
  3. ↑ Lambré, Claude; Barat Baviera, José Manuel; Bolognesi, Claudia; et al. (2024). "Safety evaluation of the food enzyme 3-phytase from the genetically modified Aspergillus niger strain NPH". EFSA Journal. 22 (1) e8514. doi:10.2903/j.efsa.2024.8514. PMC 10784861. PMID 38222927.
  4. ↑ Enzyme 3.1.3.8 at KEGG Pathway Database.