4-phytase

4-phytase
Identifiers
EC no.3.1.3.26
CAS no.9001-89-2
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme 4-phytase (EC 3.1.3.26) catalyzes the following reaction:

2D representation of the chemical structure of phytic acid .
phytic acid
 
H2O
Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right
 
 
 
2D representation of the chemical structure of Q27104611.
1D-myo-inositol 1,2,3,5,6-pentakisphosphate

The enzyme characterised from wheat bran hydrolyses phytic acid (myo-inositol hexakisphosphate) to 1D-myo-inositol 1,2,3,5,6-pentakisphosphate and orthophosphate (Pi). Addition of this enzyme to the diet of broiler chickens has been shown to prevent loss of nutrients in their excretions.

The enzymes is a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name of this enzyme class is myo-inositol-hexakisphosphate 4-phosphohydrolase. Other names in common use include 6-phytase (name based on 1L-numbering system and not 1D-numbering) and phytate 6-phosphatase.

See also

References

  1. ↑ Lim, P.E.; Tate, M.E. (1973). "The phytases. II. Properties of phytase fractions F1 and F2 from wheat bran and the myo-inositol phosphates produced by fraction F2". Biochimica et Biophysica Acta (BBA) - Enzymology. 302 (2): 316–328. doi:10.1016/0005-2744(73)90160-5. PMID 4349266.
  2. ↑ Mullaney EJ, Ullah AH (December 2003). "The term phytase comprises several different classes of enzymes". Biochemical and Biophysical Research Communications. 312 (1): 179–84. Bibcode:2003BBRC..312..179M. doi:10.1016/j.bbrc.2003.09.176. PMID 14630039.
  3. ↑ Cowieson, A.J.; Acamovic, T.; Bedford, M.R. (2004). "The effects of phytase and phytic acid on the loss of endogenous amino acids and minerals from broiler chickens". British Poultry Science. 45 (1): 101–108. doi:10.1080/00071660410001668923. PMID 15115207.
  4. ↑ Nezhad, Nima Ghahremani; Rahman, Raja Noor Zaliha Raja Abd; Normi, Yahaya M.; Oslan, Siti Nurbaya; Shariff, Fairolniza Mohd; Leow, Thean Chor (2023). "Isolation, screening and molecular characterization of phytase-producing microorganisms to discover the novel phytase". Biologia. 78 (9): 2527–2537. doi:10.1007/s11756-023-01391-w.
  5. ↑ Enzyme 3.1.3.26 at KEGG Pathway Database.