January 6–Basarab VI is installed as the new Prince of Wallachia (now in Romania) in the capital at Târgoviște, days after the assassination of the Voivode Radu of Afumați by the other boyars (Wallachian nobles). Basarab's reign lasts only a month and he is removed on February 5.
January 20– In India, the Mughal Emperor Babur departs from the capital at Agra toward Ghazipur to fight the Rajputs and the rebel Afghans who had captured the city.
January 28–Peter Vannes, the Italian-born envoy for England's King Henry VIII, arrives in Rome on a mission to get Pope Clement VII to give a dispensation for King Henry to divorce one wife and marry another, with both marriages to be declared valid. The mission fails.
March 25– A blood libel is carried out against the Jewish community of Bosen in Hungary (now Pezinok in Slovakia), on the first day of Passover, after a boy in the town disappears. Three Jews are accused and killed. The boy is later discovered alive, having been kidnapped for the benefit of the scheme.
King Henry VIII and Queen consort Catherine of Aragon appear in person before the Blackfriars court, with Catherine making a pathetic display before the court and her husband, and the king making a speech about his uneasiness about his marriage.
July–September
July 23– The Blackfriars court is adjourned after word is received that Pope Clement VII has revoked its charter.