ATP2A3 Protein-coding gene in the species Homo sapiens
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene .
This gene encodes one of the SERCA Ca2+ -ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of cells. SERCA3 expression was originally described as non-muscular, but was recently observed in cardiomyocyte . This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen , and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.
References
1 2 3 GRCh38: Ensembl release 89: ENSG00000074370 – Ensembl , May 20171 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020788 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Dode L, Wuytack F, Kools PF, Baba-Aissa F, Raeymaekers L, Brike F, van de Ven WJ, Casteels R (Nov 1996). "cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca2+ -ATPase 3 gene" . Biochem J . 318 (2): 689– 99. doi :10.1042/bj3180689 . PMC 1217674 PMID 8809064 . 1 2 "Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous" .1 2 Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol . 230 (4): 802– 812. doi :10.1002/jcp.24808 . hdl :11392/2066612 . PMID 25205602 . S2CID 24986454 .
Further reading
Wuytack F, Papp B, Verboomen H, et al. (1994). "A sarco/endoplasmic reticulum Ca2+ -ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells" . J. Biol. Chem . 269 (2): 1410– 6. doi :10.1016/S0021-9258(17)42273-3 PMID 8288608 . Dode L, De Greef C, Mountain I, et al. (1998). "Structure of the human sarco/endoplasmic reticulum Ca2+ -ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA" . J. Biol. Chem . 273 (22): 13982– 94. doi :10.1074/jbc.273.22.13982 PMID 9593748 . Poch E, Leach S, Snape S, et al. (1999). "Functional characterization of alternatively spliced human SERCA3 transcripts" . Am. J. Physiol . 275 (6 Pt 1): C1449–58. doi :10.1152/ajpcell.1998.275.6.C1449 PMID 9843705 . Martin V, Bredoux R, Corvazier E, et al. (2002). "Three novel sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family" . J. Biol. Chem . 277 (27): 24442– 52. doi :10.1074/jbc.M202011200 PMID 11956212 . Gélébart P, Kovács T, Brouland JP, et al. (2002). "Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation" . J. Biol. Chem . 277 (29): 26310– 20. doi :10.1074/jbc.M201747200 PMID 11986315 . Dode L, Vilsen B, Van Baelen K, et al. (2003). "Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+ -ATPase (SERCA) 1 and 3 isoforms by steady-state and transient kinetic analyses" . J. Biol. Chem . 277 (47): 45579– 91. doi :10.1074/jbc.M207778200 PMID 12207029 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Houston R (2003). "Longitudinal sections of unfixed muscle". Biotechnic & Histochemistry . 77 (4): 229– 30. PMID 12503734 . Borge PD, Wolf BA (2003). "Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells" . J. Biol. Chem . 278 (13): 11359– 68. doi :10.1074/jbc.M209521200 PMID 12524443 . Chandrasekera CP, Lytton J (2003). "Inhibition of human SERCA3 by PL/IM430. Molecular analysis of the interaction" . J. Biol. Chem . 278 (14): 12482– 8. doi :10.1074/jbc.M212745200 PMID 12540840 . Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol . 21 (5): 566– 9. doi :10.1038/nbt810 . PMID 12665801 . S2CID 23783563 . Bobe R, Bredoux R, Corvazier E, et al. (2004). "Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca2+ ATPase 3 gene" . J. Biol. Chem . 279 (23): 24297– 306. doi :10.1074/jbc.M314286200 PMID 15028735 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Brouland JP, Gélébart P, Kovàcs T, et al. (2005). "The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis" . Am. J. Pathol . 167 (1): 233– 42. doi :10.1016/S0002-9440(10)62968-9 . PMC 1603437 PMID 15972967 . Hadri L, Pavoine C, Lipskaia L, et al. (2006). "Transcription of the sarcoplasmic/endoplasmic reticulum Ca2+ -ATPase type 3 gene, ATP2A3, is regulated by the calcineurin/NFAT pathway in endothelial cells" . Biochem. J . 394 (Pt 1): 27– 33. doi :10.1042/BJ20051387 . PMC 1385999 PMID 16250893 . Wootton LL, Michelangeli F (2006). "The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors" . J. Biol. Chem . 281 (11): 6970– 6. doi :10.1074/jbc.M510978200 PMID 16410239 . Chaâbane C, Corvazier E, Bredoux R, et al. (2006). "Sarco/endoplasmic reticulum Ca2+ ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress". Biochem. Biophys. Res. Commun . 345 (4): 1377– 85. doi :10.1016/j.bbrc.2006.05.054 . PMID 16725111 . Bredoux R, Corvazier E, Dally S, et al. (2006). "Human platelet Ca2+ -ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis". Platelets . 17 (6): 421– 33. doi :10.1080/09537100600758719 . PMID 16973504 . S2CID 24473757 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
