B115

B115
Names
IUPAC name
1-Methyl-4-[(E)-2-naphthalen-1-ylethenyl]-3,6-dihydro-2H-pyridine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C18H19N/c1-19-13-11-15(12-14-19)9-10-17-7-4-6-16-5-2-3-8-18(16)17/h2-11H,12-14H2,1H3/b10-9+
    Key: BPVAGRSEOWNGCE-MDZDMXLPSA-N
  • CN1CCC(=CC1)/C=C/C2=CC=CC3=CC=CC=C32
Properties
C18H19N
Molar mass 249.357 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

B115 (IUPAC name 1-methyl-4-[(E)-2-naphthalen-1-ylethenyl]-3,6-dihydro-2H-pyridine) is an inhibitor of the enzyme choline acetyltransferase (ChAT).

In vivo activity

B115 inhibits human ChAT with an IC50 of 4.3 μM. During in vivo testing, B115 has been found to partially protect against soman, a nerve agent, but it has been suggested that this may not be due to ChAT inhibition.

References

  1. ↑ PubChem. "1-Methyl-4-(1-naphthylvinyl)-1,2,3,6-tetrahydropyridine hydrochloride". pubchem.ncbi.nlm.nih.gov. Retrieved 2026-01-02.
  2. ↑ "AID 52122 - Inhibition of choline acetyltransferase (CAT) enzyme - PubChem". pubchem.ncbi.nlm.nih.gov. Retrieved 2026-01-02.
  3. ↑ Gray, A. P.; Platz, R. D.; Henderson, T. R.; Chang, T. C.; Takahashi, K.; Dretchen, K. L. (April 1, 1988). "Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes". Journal of Medicinal Chemistry. 31 (4): 807–814. doi:10.1021/jm00399a022. ISSN 0022-2623. PMID 3351860.
  4. ↑ Henderson, T. R.; Gray, A. P.; Platz, R. D.; Kellar, K. J.; Dretchen, K. L. (1991). "Inhibition of brain choline acetyltransferase in vivo: (E)-1-methyl-4-(1-naphthylvinyl)-1,2,3,6-tetrahydropyridine hydrochloride (B115), a depot form of a potent inhibitor". Toxicology and Applied Pharmacology. 107 (2): 336–343. Bibcode:1991ToxAP.107..336H. doi:10.1016/0041-008x(91)90213-x. ISSN 0041-008X. PMID 1994515.