ZNG1B

ZNG1B
Identifiers
Aliases	ZNG1B, COBW domain containing 2, CBWD2, Zn regulated GTPase metalloprotein activator 1B
External IDs	OMIM: 611079; MGI: 2385089; GeneCards: ZNG1B
Gene location (Human)
Chr.	Chromosome 2 (human)
End	113,496,204 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	24,938,974 bp
RNA expression pattern
	Top expressed in
	monocyte; ; islet of Langerhans; ; anterior pituitary; ; right adrenal cortex; ; body of pancreas; ; left adrenal gland; ; left adrenal cortex; ; left lobe of thyroid gland; ; gastrocnemius muscle; ; left ventricle;
	Top expressed in
	spermatocyte; ; morula; ; spermatid; ; seminiferous tubule; ; tail of embryo; ; primitive streak; ; interventricular septum; ; lumbar spinal ganglion; ; muscle of thigh; ; embryo;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	150472
	226043
	ENSG00000136682
	ENSMUSG00000024878
	Q8IUF1
	Q8VEH6
NM_172003; NM_001330336; NM_001330337; NM_001330339; NM_001330340;
	NM_001330342
	NM_146097
NP_001317265; NP_001317266; NP_001317268; NP_001317269; NP_001317271;
	NP_742000
	NP_666209
	Wikidata
View/Edit Human	View/Edit Mouse

COBW domain containing 2 is a protein that in humans is encoded by the CBWD2 gene. Like ZNG1A, research in mice suggests that this protein activates metalloproteins like METAP1 by transferring zinc to them.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136682 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024878 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: COBW domain containing 2". Retrieved 2018-02-05.
↑ "Zinc-regulated GTPase metalloprotein activator 1B". uniprot.org. UniProt consortium. Retrieved 2026-09-11.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136682 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024878 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: COBW domain containing 2". Retrieved 2018-02-05.

[6] "Zinc-regulated GTPase metalloprotein activator 1B". uniprot.org. UniProt consortium. Retrieved 2026-09-11.