C-C motif chemokine ligand 24

Search for
Structures	Swiss-model
Domains	InterPro

chemokine (C-C motif) ligand 24
chemokine (C-C motif) ligand 24
Identifiers
Symbol	CCL24
Alt. symbols	SCYA24, Ckb-6, MPIF-2, eotaxin-2
NCBI gene	6369
HGNC	10623
OMIM	602495
PDB	1EIG
RefSeq	NM_002991
UniProt	O00175
Other data
Locus	Chr. 7 q11.23
Structures
Search for
Structures	Swiss-model
Domains	InterPro

CCL24
Identifiers
Aliases	CCL24, Ckb-6, MPIF-2, MPIF2, SCYA24, C-C motif chemokine ligand 24
External IDs	OMIM: 602495; MGI: 1928953; GeneCards: CCL24
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EIG, 1EIH
Gene location (Human)
Chr.	Chromosome 7 (human)
End	75,823,356 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,601,903 bp
RNA expression pattern
	Top expressed in
	rectum; ; spleen; ; mucosa of transverse colon; ; appendix; ; duodenum; ; lymph node; ; jejunal mucosa; ; right coronary artery; ; mucosa of sigmoid colon; ; upper lobe of left lung;
	Top expressed in
	muscle of thigh; ; lip; ; white adipose tissue; ; esophagus; ; skeletal muscle tissue; ; jejunum; ; migratory enteric neural crest cell; ; subcutaneous adipose tissue; ; dermis; ; stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; chemokine activity; CCR3 chemokine receptor binding; receptor ligand activity; protein binding; CCR chemokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	eosinophil chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of GTPase activity; positive regulation of angiogenesis; G protein-coupled receptor signaling pathway; cell-cell signaling; positive regulation of eosinophil migration; chemotaxis; cytoskeleton organization; lymphocyte chemotaxis; positive regulation of cell migration; cellular response to tumor necrosis factor; chemokine-mediated signaling pathway; cellular response to interleukin-1; cellular response to interferon-gamma; positive regulation of actin filament polymerization; signal transduction; regulation of cell shape; immune response; inflammatory response; positive regulation of inflammatory response; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6369
	56221
	ENSG00000106178
	ENSMUSG00000004814
	O00175
	Q9JKC0
	NM_002991; NM_001371193
	NM_019577; NM_001356630
	NP_002982; NP_001358122
	NP_062523; NP_001343559
	Wikidata
View/Edit Human	View/Edit Mouse

C-C motif chemokine ligand 24 is a protein that in humans is encoded by the CCL24 gene. CCL24 is also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic protein 2 (eotaxin-2).

Function

CCL24 belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line.

Clinical significance

Elevated levels of eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000106178 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004814 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: C-C motif chemokine ligand 24". Retrieved 2018-05-09.
↑ White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM (November 1997). "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils". J. Leukoc. Biol. 62 (5): 667–75. doi:10.1002/jlb.62.5.667. PMID 9365122. S2CID 12197497.
↑ Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G (April 1997). "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors". J. Exp. Med. 185 (7): 1163–72. doi:10.1084/jem.185.7.1163. PMC 2196270. PMID 9104803.
↑ Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS (October 2009). "Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease". Allergy. 65 (3): 338–346. doi:10.1111/j.1398-9995.2009.02158.x. PMID 19796209. S2CID 205404242.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Papadopoulos NG, Papi A, Meyer J, Stanciu LA, Salvi S, Holgate ST, Johnston SL (July 2001). "Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells". Clin. Exp. Allergy. 31 (7): 1060–6. doi:10.1046/j.1365-2222.2001.01112.x. PMID 11467997. S2CID 20581201.
Tachimoto H, Kikuchi M, Hudson SA, Bickel CA, Hamilton RG, Bochner BS (June 2002). "Eotaxin-2 alters eosinophil integrin function via mitogen-activated protein kinases". Am. J. Respir. Cell Mol. Biol. 26 (6): 645–9. doi:10.1165/ajrcmb.26.6.4741. PMID 12034562.
Badewa AP, Hudson CE, Heiman AS (September 2002). "Regulatory effects of eotaxin, eotaxin-2, and eotaxin-3 on eosinophil degranulation and superoxide anion generation". Exp. Biol. Med. (Maywood). 227 (8): 645–51. doi:10.1177/153537020222700814. PMID 12192108. S2CID 32212646.
Menzies-Gow A, Ying S, Sabroe I, Stubbs VL, Soler D, Williams TJ, Kay AB (September 2002). "Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers". J. Immunol. 169 (5): 2712–8. doi:10.4049/jimmunol.169.5.2712. PMID 12193745.
Chae SC, Lee YC, Park YR, Shin JS, Song JH, Oh GJ, Hong ST, Pae HO, Choi BM, Chung HT (July 2004). "Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil". Biochem. Biophys. Res. Commun. 320 (1): 131–7. doi:10.1016/j.bbrc.2004.05.136. PMID 15207712.
Chae SC, Park YR, Oh GJ, Lee JH, Chung HT (January 2005). "The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis". Immunogenetics. 56 (10): 760–4. doi:10.1007/s00251-004-0746-2. PMID 15580493. S2CID 45416407.
Min JW, Lee JH, Park CS, Chang HS, Rhim TY, Park SW, Jang AS, Shin HD (2005). "Association of eotaxin-2 gene polymorphisms with plasma eotaxin-2 concentration". J. Hum. Genet. 50 (3): 118–23. doi:10.1007/s10038-005-0230-3. PMID 15744457.
Min JW, Jang AS, Park SM, Lee SH, Lee JH, Park SW, Park CS (November 2005). "Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients". Chest. 128 (5): 3127–32. doi:10.1378/chest.128.5.3127. PMID 16304252.
Park YR, Choi SC, Lee ST, Kim KS, Chae SC, Chung HT (December 2005). "The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis". Exp. Mol. Med. 37 (6): 553–8. doi:10.1038/emm.2005.68. PMID 16391516.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000106178 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004814 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: C-C motif chemokine ligand 24". Retrieved 2018-05-09.

[pmid9365122-6] White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM (November 1997). "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils". J. Leukoc. Biol. 62 (5): 667–75. doi:10.1002/jlb.62.5.667. PMID 9365122. S2CID 12197497.

[pmid9104803-7] Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G (April 1997). "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors". J. Exp. Med. 185 (7): 1163–72. doi:10.1084/jem.185.7.1163. PMC 2196270. PMID 9104803.

[pmid19796209-8] Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS (October 2009). "Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease". Allergy. 65 (3): 338–346. doi:10.1111/j.1398-9995.2009.02158.x. PMID 19796209. S2CID 205404242.

C-C motif chemokine ligand 24

Function

Clinical significance

References

Further reading