CCL26

CCL26
Identifiers
Aliases	CCL26, IMAC, MIP-4a, MIP-4alpha, SCYA26, TSC-1, C-C motif chemokine ligand 26
External IDs	OMIM: 604697; MGI: 3589281; GeneCards: CCL26
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G2S, 1G2T
Gene location (Human)
Chr.	Chromosome 7 (human)
End	75,789,896 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,592,423 bp
RNA expression pattern
	Top expressed in
	testicle; ; right ovary; ; left ovary; ; tibial nerve; ; anterior pituitary; ; gonad; ; left uterine tube; ; right adrenal gland; ; ectocervix; ; left adrenal gland;
	Top expressed in
	spermatid; ; testicle; ; jejunum; ; lens; ; colon; ; torso; ; heart;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; chemokine activity; CCR3 chemokine receptor binding; receptor ligand activity; protein binding; CCR chemokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of endothelial cell proliferation; positive regulation of actin filament polymerization; positive regulation of cell migration; cellular response to tumor necrosis factor; cell-cell signaling; neutrophil chemotaxis; chemotaxis; positive regulation of GTPase activity; cellular response to interleukin-1; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; signal transduction; immune response; inflammatory response; monocyte chemotaxis; T cell chemotaxis; positive regulation of chemotaxis; chemokine-mediated signaling pathway; regulation of signaling receptor activity; eosinophil chemotaxis; lymphocyte chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10344
	541307
	ENSG00000006606
	ENSMUSG00000070464
	Q9Y258
	F8VQM2
	NM_006072; NM_001371936; NM_001371938
	NM_001013412
	NP_006063; NP_001358865; NP_001358867
	NP_001013430
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-C motif) ligand 26 (CCL26) is a small cytokine belonging to the CC chemokine family that is also called Eotaxin-3, Macrophage inflammatory protein 4-alpha (MIP-4-alpha), Thymic stroma chemokine-1 (TSC-1), and IMAC. It is expressed by several tissues including heart, lung and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4. CCL26 is chemotactic for eosinophils and basophils and elicits its effects by binding to the cell surface chemokine receptor CCR3. This gene for chemokine is located on human chromosome 7.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000006606 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070464 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Shinkai et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J. Immunol. 163:1602-1610, 1999.
↑ Guo et al. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. Genomics 58:313-317, 1999.
↑ Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999.
↑ Hillier et al. The DNA sequence of human chromosome 7. Nature 424:157-164, 2003.

External links

CCL26 human gene location in the UCSC Genome Browser.
CCL26 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000006606 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070464 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Shinkai et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J. Immunol. 163:1602-1610, 1999.

[6] Guo et al. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. Genomics 58:313-317, 1999.

[7] Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999.

[8] Hillier et al. The DNA sequence of human chromosome 7. Nature 424:157-164, 2003.