Carboxypeptidase A1

CPA1
Identifiers
Aliases	CPA1, CPA, carboxypeptidase A1
External IDs	OMIM: 114850; MGI: 88478; GeneCards: CPA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2V77, 3FJU, 4UEZ, 4UF4, 4UEE, 4UEF
Enzyme activity
Gene location (Human)
Chr.	Chromosome 7 (human)
End	130,388,114 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	30,645,362 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; beta cell; ; testicle; ; ectocervix; ; right coronary artery; ; right lobe of liver; ; left uterine tube; ; canal of the cervix; ; right uterine tube;
	Top expressed in
	pyloric antrum; ; islet of Langerhans; ; secondary oocyte; ; primary oocyte; ; zygote; ; migratory enteric neural crest cell; ; duodenum; ; embryo; ; sexually immature organism; ; Gonadal ridge;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carboxypeptidase activity; zinc ion binding; peptidase activity; exopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metallocarboxypeptidase activity; protein binding;
Cellular component	extracellular region; extracellular space;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1357
	109697
	ENSG00000091704
	ENSMUSG00000054446
	P15085
	Q7TPZ8
	NM_001868
	NM_025350
	NP_001859
	NP_079626
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxypeptidase A1 is an enzyme that in humans is encoded by the CPA1 gene. This protein functions as a digestive enzyme which is secreted (in inactive form) into pancreatic juice by the acinar cells of the pancreas.

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The CPA1 and CPA2 forms are monomeric proteins with different biochemical properties. Carboxypeptidase A1 is a monomeric pancreatic exopeptidase. It is involved in zymogen inhibition.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000091704 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054446 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: CPA1 carboxypeptidase A1 (pancreatic)".
↑ Pandol SJ (2010). "Anatomy". The Exocrine Pancreas. Morgan & Claypool Life Science.
↑ "CPA1". The Human Protein Atlas. Retrieved 2026-09-21.

External links

The MEROPS online database for peptidases and their inhibitors: M14.001^{[dead link]}
Overview of all the structural information available in the PDB for UniProt: P15085 (Carboxypeptidase A1) at the PDBe-KB.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000091704 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054446 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: CPA1 carboxypeptidase A1 (pancreatic)".

[pandol2010-6] Pandol SJ (2010). "Anatomy". The Exocrine Pancreas. Morgan & Claypool Life Science.

[7] "CPA1". The Human Protein Atlas. Retrieved 2026-09-21.

Carboxypeptidase A1

References

Further reading

External links