Exportin-2
| CSE1L | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | CSE1L, CAS, CSE1, XPO2, chromosome segregation 1 like | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 601342; MGI: 1339951; GeneCards: CSE1L | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Exportin-2 is a protein that in humans is encoded by the CSE1L gene (previously CAS). It functions an exportin which in the nucleus is bound to RanGTP.
Function
The Cas family of proteins are a family of proteins that induce cellular apoptosis and cell proliferation. Apoptosis is a specialized sequence of events that a cell can induce for programmed death. Cas is a 2 terminal protein, a N-terminal and a C-terminal, and there is a positive correlation between the presence of CAS and the degree of cellular proliferation. Along with this correlation, in the absence of the CAS protein in a cell, there is an inhibition of apoptosis Along with being an inducer of apoptosis, CAS also plays a role in being a checkpoint for cell cycle. Without the CAS protein, a cell will not be able to go beyond the G2 phase. It is in the nucleus of the cell, where its exportin function comes into play.
See also
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000124207 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002718 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 Jiang MC (October 2016). "CAS (CSE1L) signaling pathway in tumor progression and its potential as a biomarker and target for targeted therapy". Tumour Biology. 37 (10): 13077–13090. doi:10.1007/s13277-016-5301-x. PMID 27596143. S2CID 31420897.
External links
- Cellular+Apoptosis+Susceptibility+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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