Cyclin-dependent kinase 19

CDK19
Identifiers
Aliases	CDK19, CDC2L6, CDK11, bA346C16.3, cyclin-dependent kinase 19, cyclin dependent kinase 19, DEE87, EIEE87
External IDs	OMIM: 614720; MGI: 1925584; GeneCards: CDK19
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	110,815,958 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	40,359,814 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; internal globus pallidus; ; corpus callosum; ; optic nerve; ; external globus pallidus; ; inferior olivary nucleus; ; inferior ganglion of vagus nerve; ; middle frontal gyrus; ; C1 segment; ; ganglionic eminence;
	Top expressed in
	otolith organ; ; utricle; ; vestibular membrane of cochlear duct; ; hand; ; stria vascularis; ; lobe of cerebellum; ; neural layer of retina; ; prostate; ; blood; ; sciatic nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; ATP binding; cyclin-dependent protein serine/threonine kinase activity; enzyme binding;
Cellular component	nucleus; cytosol; mediator complex;
Biological process	positive regulation of inflammatory response; cellular response to lipopolysaccharide; phosphorylation; positive regulation of apoptotic process; protein phosphorylation; regulation of mitotic cell cycle; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23097
	78334
	ENSG00000155111
	ENSMUSG00000038481
	Q9BWU1
	Q8BWD8
	NM_001300960; NM_001300963; NM_001300964; NM_015076
	NM_001168304; NM_001291816; NM_001291817; NM_198164
	NP_001287889; NP_001287892; NP_001287893; NP_055891
	NP_001161776; NP_001278745; NP_001278746; NP_937807
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 19 (or CDK19) is an enzyme that in humans is encoded by the CDK19 gene.

Inhibitors

The natural product cortistatin A is a potent and selective inhibitor of CDK8 and CDK19.

Romaciclib is a dual CDK8 and CDK19 inhibitor which is being developed for the treatment of acute myeloid leukaemia (AML).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000155111 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038481 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, et al. (August 2018). "Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer". Oncogene. 37 (35): 4792–4808. doi:10.1038/s41388-018-0316-y. PMC 7018387. PMID 29780169.
↑ Fant CB, Taatjes DJ (April 2019). "Regulatory functions of the Mediator kinases CDK8 and CDK19". Transcription. 10 (2): 76–90. doi:10.1080/21541264.2018.1556915. PMC 6602567. PMID 30585107.
↑ Dannappel MV, Sooraj D, Loh JJ, Firestein R (2018). "Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules". Frontiers in Cell and Developmental Biology. 6 171. doi:10.3389/fcell.2018.00171. PMC 6340071. PMID 30693281.
↑ Pelish HE, Liau BB, Nitulescu II, Tangpeerachaikul A, Poss ZC, Da Silva DH, et al. (Oct 2015). "Mediator kinase inhibition further activates super-enhancer-associated genes in AML". Nature. 526 (7572): 273–6. Bibcode:2015Natur.526..273P. doi:10.1038/nature14904. PMC 4641525. PMID 26416749.
↑ "Romaciclib - Ryvu Therapeutics". AdisInsight. Springer Nature Switzerland AG.
↑ Rajendra A, Yee KW (April 2026). "Clinical development of a CDK8/19 kinase inhibitor for acute myeloid leukemia". Expert Opinion on Investigational Drugs. 35 (4): 253–256. doi:10.1080/13543784.2026.2656430. PMID 41931045.
↑ Pakulska U, Obacz M, Woźnicki J, Wiklik K, Chakraborty S, Micek M, et al. (January 2026). "Romaciclib, a CDK8/CDK19 inhibitor, can overcome venetoclax resistance through a combinatorial strategy". bioRxiv 10.64898/2025.12.16.693978.

External links

CDK19+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
CDK19 human gene location in the UCSC Genome Browser.
CDK19 human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000155111 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038481 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Serrao_2018-5] Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, et al. (August 2018). "Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer". Oncogene. 37 (35): 4792–4808. doi:10.1038/s41388-018-0316-y. PMC 7018387. PMID 29780169.

[Fant_2019-6] Fant CB, Taatjes DJ (April 2019). "Regulatory functions of the Mediator kinases CDK8 and CDK19". Transcription. 10 (2): 76–90. doi:10.1080/21541264.2018.1556915. PMC 6602567. PMID 30585107.

[Dannappel_2018-7] Dannappel MV, Sooraj D, Loh JJ, Firestein R (2018). "Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules". Frontiers in Cell and Developmental Biology. 6 171. doi:10.3389/fcell.2018.00171. PMC 6340071. PMID 30693281.

[8] Pelish HE, Liau BB, Nitulescu II, Tangpeerachaikul A, Poss ZC, Da Silva DH, et al. (Oct 2015). "Mediator kinase inhibition further activates super-enhancer-associated genes in AML". Nature. 526 (7572): 273–6. Bibcode:2015Natur.526..273P. doi:10.1038/nature14904. PMC 4641525. PMID 26416749.

[9] "Romaciclib - Ryvu Therapeutics". AdisInsight. Springer Nature Switzerland AG.

[Rajendra_2026-10] Rajendra A, Yee KW (April 2026). "Clinical development of a CDK8/19 kinase inhibitor for acute myeloid leukemia". Expert Opinion on Investigational Drugs. 35 (4): 253–256. doi:10.1080/13543784.2026.2656430. PMID 41931045.

[Pakulska_2026-11] Pakulska U, Obacz M, Woźnicki J, Wiklik K, Chakraborty S, Micek M, et al. (January 2026). "Romaciclib, a CDK8/CDK19 inhibitor, can overcome venetoclax resistance through a combinatorial strategy". bioRxiv 10.64898/2025.12.16.693978.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)