SGK2

SGK2
Identifiers
AliasesSGK2, H-dJ138B7.2, serine/threonine kinase 2, serum/glucocorticoid regulated kinase 2
External IDsOMIM: 607589; MGI: 1351318; GeneCards: SGK2
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
2.7.11.1↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

10110

27219

Ensembl

ENSG00000101049

ENSMUSG00000017868

UniProt

Q9HBY8
Q5H8Y5

Q9QZS5

RefSeq (mRNA)

NM_170693
NM_001199264
NM_016276

NM_001291152
NM_001291154
NM_013731

RefSeq (protein)

NP_001186193
NP_057360
NP_733794

NP_001278081
NP_001278083
NP_038759

Location (UCSC)Chr 20: 43.56 – 43.59 MbChr 2: 162.83 – 162.86 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene.

This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase (PI3K), which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described.

Ligands

Privosegtor, an activator of the SGK2 enzyme, is being developed for the treatment of optic neuritis.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000101049 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017868 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Kobayashi T, Deak M, Morrice N, Cohen P (January 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". The Biochemical Journal. 344 (1): 189–197. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550.
  6. 1 2 "Entrez Gene: SGK2 serum/glucocorticoid regulated kinase 2".
  7. ↑ "Privosegtor - Oculis Pharma". AdisInsight. Springer Nature Switzerland AG.

Further reading

  • Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms". Science's STKE. 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID 11707620. S2CID 25927734.
  • Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, et al. (October 2002). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflugers Archiv. 445 (1): 60–66. doi:10.1007/s00424-002-0873-2. PMID 12397388. S2CID 21073737.
  • Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, et al. (March 2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC". Pflugers Archiv. 445 (6): 693–696. doi:10.1007/s00424-002-0993-8. PMID 12632189. S2CID 32511608.
  • Embark HM, Böhmer C, Vallon V, Luft F, Lang F (February 2003). "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms". Pflugers Archiv. 445 (5): 601–606. doi:10.1007/s00424-002-0982-y. PMID 12634932. S2CID 22981271.
  • Baltaev R, Strutz-Seebohm N, Korniychuk G, Myssina S, Lang F, Seebohm G (April 2005). "Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes". Pflugers Archiv. 450 (1): 26–33. doi:10.1007/s00424-004-1369-z. PMID 15578212. S2CID 190895.
  • Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, et al. (May 2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725). New York, N.Y.: 1149–1154. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.