ACVR2B

Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor.

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

ACVR2B has been shown to interact with ACVR1B and SYNJ2BP.

• Human ACVR2B genome location and ACVR2B gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q13705 (Human Activin receptor type-2B) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: P27040 (Mouse Activin receptor type-2B) at the PDBe-KB.