MYLK4

MYLK4
Identifiers
Aliases	MYLK4, SgK085, myosin light chain kinase family member 4
External IDs	MGI: 3643758; GeneCards: MYLK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X4F
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	2,750,922 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	32,967,937 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; deltoid muscle; ; Skeletal muscle tissue of biceps brachii; ; buccal mucosa cell; ; Skeletal muscle tissue of rectus abdominis; ; body of tongue; ; muscle of thigh; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; gastrocnemius muscle;
	Top expressed in
	muscle of thigh; ; knee joint; ; triceps brachii muscle; ; vastus lateralis muscle; ; skeletal muscle tissue; ; interventricular septum; ; gastrocnemius muscle; ; temporal muscle; ; extraocular muscle; ; medial head of gastrocnemius muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; ATP binding; kinase activity; myosin light chain kinase activity;
Cellular component	intracellular anatomical structure;
Biological process	protein phosphorylation; phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	340156
	238564
	ENSG00000145949
	ENSMUSG00000044951
	Q86YV6
	Q5SUV5
	NM_001012418; NM_001347872
	NM_001166030; NM_001368880
	NP_001012418; NP_001334801
	NP_001159502
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin light chain kinase 4 also known as MYLK4 is an enzyme which in humans is encoded by the MYLK4 gene. MYLK4 is a member of the myosin light-chain kinase family of serine/threonine-specific protein kinases that phosphorylate the regulatory light chain of myosin II.

This protein acts as an enzyme that catalyzes the following reaction: ATP + a protein -> ADP + a phosphoprotein.

MYLK4 is also involved in protein amino acid phosphorylation meaning that it adds a phosphate group onto the molecule.

Not very much is known about the specific functional characteristics of MLYK4, but it has recently been found that the gene may possibly have a role in having at least one driver mutation for cancer. MYLK4 may also be involved in transferase activity, ATP binding, protein serine/threonine kinase activity, and also nucleotide binding. Other names for MYLK4 are CaMLCK like; EG238564; MYLK4; Mylk4; Myosin light chain kinase family, member 4; SgK085; SGK085; Sgk085; Sugen kinase 85; Uncharacterized serine/threonine-protein kinase SgK085.

There are other known myosin light-chain kinase enzymes.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000145949 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044951 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156".
↑ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–34. Bibcode:2002Sci...298.1912M. doi:10.1126/science.1075762. PMID 12471243. S2CID 26554314.
↑ Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K (June 2001). "Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction". IUBMB Life. 51 (6): 337–44. doi:10.1080/152165401753366087. PMID 11758800. S2CID 46180993.
↑ "MYLK4 - Protein (Function), MYLK4 - Protein (Function)".{{cite web}}: CS1 maint: deprecated archival service (link)
↑ "www.phosphosite.org".
↑ "SGC | Human Myosin Light Chain Kinase Family Member 4 (LOC340156) PDB Code: 2X4F".
↑ "MYLK4 Gene - GeneCards | MYLK4 Protein | MYLK4 Antibody".
↑ "Sgk085 : Protein Overview : UCSD Molecule Pages". Archived from the original on 2011-07-22. Retrieved 2011-04-26.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000145949 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044951 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2X4F-5] "RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156".

[pmid12471243-6] Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–34. Bibcode:2002Sci...298.1912M. doi:10.1126/science.1075762. PMID 12471243. S2CID 26554314.

[pmid11758800-7] Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K (June 2001). "Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction". IUBMB Life. 51 (6): 337–44. doi:10.1080/152165401753366087. PMID 11758800. S2CID 46180993.

[urlMYLK4_-_Protein_(Function),_MYLK4_-_Protein_(Function)-8] "MYLK4 - Protein (Function), MYLK4 - Protein (Function)".{{cite web}}: CS1 maint: deprecated archival service (link)

[urlwww.phosphosite.org-9] "www.phosphosite.org".

[urlSGC_|_Human_Myosin_Light_Chain_Kinase_Family_Member_4_(LOC340156)_PDB_Code:_2X4F-10] "SGC | Human Myosin Light Chain Kinase Family Member 4 (LOC340156) PDB Code: 2X4F".

[urlMYLK4_Gene_-_GeneCards_|_MYLK4_Protein_|_MYLK4_Antibody-11] "MYLK4 Gene - GeneCards | MYLK4 Protein | MYLK4 Antibody".

[urlSgk085_:_Protein_Overview_:_UCSD_Molecule_Pages-12] "Sgk085 : Protein Overview : UCSD Molecule Pages". Archived from the original on 2011-07-22. Retrieved 2011-04-26.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)