PNCK

PNCK
Identifiers
Aliases	PNCK, BSTK3, CaMK1b, pregnancy up-regulated nonubiquitous CaM kinase
External IDs	OMIM: 300680; MGI: 1347357; GeneCards: PNCK
Enzyme activity
Gene location (Human)
Chr.	X chromosome (human)
End	153,689,010 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	72,703,723 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; Brodmann area 9; ; nucleus accumbens; ; cingulate gyrus; ; anterior cingulate cortex; ; muscle layer of sigmoid colon; ; amygdala; ; caudate nucleus; ; putamen; ; prefrontal cortex;
	Top expressed in
	ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; anterior amygdaloid area; ; lateral septal nucleus; ; lateral hypothalamus; ; subiculum; ; nucleus of stria terminalis;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; ATP binding; calmodulin binding; kinase activity; calmodulin-dependent protein kinase activity;
Cellular component	cytoplasm; nucleus; intracellular anatomical structure;
Biological process	protein phosphorylation; phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	139728
	93843
	ENSG00000130822
	ENSMUSG00000002012
	Q6P2M8
	Q9QYK9
NM_001039582; NM_001135740; NM_198452; NM_001366975; NM_001366976;
	NM_001366977; NM_001366978; NM_001366979; NM_001366980
	NM_001199351; NM_001199352; NM_012040
NP_001034671; NP_001129212; NP_001353904; NP_001353905; NP_001353906;
	NP_001353907; NP_001353908; NP_001353909
	NP_001186280; NP_001186281; NP_036170
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium/calmodulin-dependent protein kinase type 1B (CAMKIβ), also called pregnancy up-regulated nonubiquitous CaM kinase (PNCK), is an enzyme that in humans is encoded by the PNCK gene. As a calcium/calmodulin-dependent protein kinase (CAMK), this enzyme acts as a second messenger involved in calcium-triggered signaling. CAMKIβ is predicted to phosphorylate (add phosphates to) CAMK1, CREB1, and SYN1.

Medical Significance

CAMKIβ, like other members of the CAMKI family, is frequently over-expressed in specific cancers. CAMKIβ specifically is overexpressed in certain types of breast cancer, and in clear renal cell carcinoma compared to benign tissue. Its expression has also correlated with the prognosis of acute myeloid leukaemia.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130822 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002012 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "Calcium/calmodulin-dependent protein kinase type 1B". uniprot.org. UniProt consortium. Retrieved 2026-10-16.
1 2 3 4 Brzozowski JS, Skelding KA (2019-01-07). "The multi-functional calcium/calmodulin stimulated protein kinase (CaMK) family: emerging targets for anti-cancer therapeutic intervention". Pharmaceuticals. 12 (1): 8. doi:10.3390/ph12010008. PMC 6469190. PMID 30621060.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000130822 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002012 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] 1 2 3 "Calcium/calmodulin-dependent protein kinase type 1B". uniprot.org. UniProt consortium. Retrieved 2026-10-16.

[Brzozowski-6] 1 2 3 4 Brzozowski JS, Skelding KA (2019-01-07). "The multi-functional calcium/calmodulin stimulated protein kinase (CaMK) family: emerging targets for anti-cancer therapeutic intervention". Pharmaceuticals. 12 (1): 8. doi:10.3390/ph12010008. PMC 6469190. PMID 30621060.