DAPK1

DAPK1
Identifiers
Aliases	DAPK1, DAPK, death associated protein kinase 1, ROCO3
External IDs	OMIM: 600831; MGI: 1916885; GeneCards: DAPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IG1, 1JKK, 1JKL, 1JKS, 1JKT, 1P4F, 1WVX, 1WVY, 1YR5, 2W4J, 2W4K, 2X0G, 2XUU, 2XZS, 2Y0A, 2Y4P, 2Y4V, 2YAK, 3DFC, 3DGK, 3EH9, 3EHA, 3F5G, 3F5U, 3GU4, 3GU5, 3GU6, 3GU7, 3GU8, 3GUB, 3ZXT, 4B4L, 4PF4, 4TL0, 4TXC, 4UV0, 4YO4, 4YPD, 5AUW, 5AUU, 5AV1, 5AUY, 5AUT, 5AUX, 5AUV, 5AUZ, 5AV0, 5AV4, 5AV2, 5AV3
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.11.1 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 9 (human) Band 9q21.33 Start 87,497,228 bp End 87,708,634 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 B2|13 32.53 cM Start 60,749,761 bp End 60,911,005 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium palpebral conjunctiva placenta left ovary middle temporal gyrus parietal pleura corpus epididymis gallbladder pancreatic ductal cell monocyte Top expressed in saccule lateral septal nucleus otic vesicle left lung lobe olfactory tubercle subiculum genital tubercle piriform cortex pineal gland anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding GTP binding syntaxin-1 binding kinase activity protein binding identical protein binding calmodulin-dependent protein kinase activity protein serine/threonine kinase activity calmodulin binding ATP binding protein kinase activity Cellular component plasma membrane actin cytoskeleton cytoskeleton cytoplasm nucleus Biological process regulation of apoptotic process negative regulation of translation phosphorylation negative regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of autophagy negative regulation of extrinsic apoptotic signaling pathway via death domain receptors apoptotic signaling pathway protein autophosphorylation regulation of translation extrinsic apoptotic signaling pathway via death domain receptors signal transduction apoptotic process regulation of NMDA receptor activity protein phosphorylation positive regulation of autophagy intracellular signal transduction cellular response to interferon-gamma cellular response to hydroperoxide Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 1612 69635 Ensembl ENSG00000196730 ENSMUSG00000021559 UniProt P53355 Q80YE7 RefSeq (mRNA) NM_001288729 NM_001288730 NM_001288731 NM_004938 NM_001285917 NM_029653 NM_134062 RefSeq (protein) NP_001275658 NP_001275659 NP_001275660 NP_004929 NP_001272846 NP_083929 NP_598823 Location (UCSC) Chr 9: 87.5 – 87.71 Mb Chr 13: 60.75 – 60.91 Mb PubMed search
Wikidata
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Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.

Function

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.

In melanocytic cells DAPK1 gene expression may be regulated by MITF.

As a drug target

Depletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor-negative breast cancer, from individuals with p53-mutant cancers. This has not been demonstrated in actual patients.