MAP3K13

MAP3K13
Identifiers
Aliases	MAP3K13, LZK, MEKK13, MLK, mitogen-activated protein kinase kinase kinase 13
External IDs	OMIM: 604915; MGI: 2444243; GeneCards: MAP3K13
Enzyme activity
Gene location (Human)
Chr.	Chromosome 3 (human)
End	185,489,094 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	21,752,189 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; caput epididymis; ; tail of epididymis; ; sperm; ; mucosa of paranasal sinus; ; lower lobe of lung; ; lactiferous duct; ; buccal mucosa cell; ; pons; ; inferior ganglion of vagus nerve;
	Top expressed in
	ureter; ; ganglionic eminence; ; neural layer of retina; ; jejunum; ; cerebellum; ; cerebellar cortex; ; colon; ; duodenum; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity; identical protein binding; kinase activity; MAP kinase kinase kinase activity; protein serine/threonine kinase activity; protein kinase activity; ATP binding; protein kinase binding; metal ion binding; nucleotide binding; transferase activity; JUN kinase kinase kinase activity; IkappaB kinase complex binding; enzyme binding;
Cellular component	membrane; cytoplasm; IkappaB kinase complex;
Biological process	phosphorylation; JNK cascade; protein phosphorylation; protein autophosphorylation; positive regulation of NF-kappaB transcription factor activity; MAPK cascade; positive regulation of neuron maturation; peptidyl-serine phosphorylation; positive regulation of axon extension; positive regulation of neuron projection arborization; positive regulation of branching morphogenesis of a nerve;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9175
	71751
	ENSG00000073803
	ENSMUSG00000033618
	O43283
	Q1HKZ5
	NM_001242314; NM_001242317; NM_004721
	NM_172821
	NP_001229243; NP_001229246; NP_004712
	NP_766409
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene.

Function

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.

Interactions

MAP3K13 has been shown to interact with PRDX3.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000073803 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033618 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T (Dec 1997). "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain". J Biol Chem. 272 (45): 28622–9. doi:10.1074/jbc.272.45.28622. PMID 9353328.
1 2 "Entrez Gene: MAP3K13 mitogen-activated protein kinase kinase kinase 13".
↑ Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T (Jan 2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. doi:10.1046/j.1432-1033.2003.03363.x. PMID 12492477.

Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T (2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. doi:10.1046/j.1432-1033.2003.03363.x. PMID 12492477.
Ikeda A, Sakuma H, Masaki M, Kozutsumi Y, Oka S, Inazawa J, Kawasaki T (2002). "Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene". J. Biochem. Mol. Biol. Biophys. 6 (2): 113–7. doi:10.1080/10258140290027243. PMID 12186766.
Ikeda A, Hasegawa K, Masaki M, Moriguchi T, Nishida E, Kozutsumi Y, Oka S, Kawasaki T (2002). "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway". J. Biochem. 130 (6): 773–81. doi:10.1093/oxfordjournals.jbchem.a003048. PMID 11726277.
Ikeda A, Masaki M, Kozutsumi Y, Oka S, Kawasaki T (2001). "Identification and characterization of functional domains in a mixed lineage kinase LZK". FEBS Lett. 488 (3): 190–5. Bibcode:2001FEBSL.488..190I. doi:10.1016/S0014-5793(00)02432-7. PMID 11163770. S2CID 44379847.
Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000073803 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033618 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9353328-5] Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T (Dec 1997). "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain". J Biol Chem. 272 (45): 28622–9. doi:10.1074/jbc.272.45.28622. PMID 9353328.

[entrez-6] 1 2 "Entrez Gene: MAP3K13 mitogen-activated protein kinase kinase kinase 13".

[pmid12492477-7] Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T (Jan 2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. doi:10.1046/j.1432-1033.2003.03363.x. PMID 12492477.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

MAP3K13

Function

Interactions

References

Further reading